Abstract

Stroke impairs neuro-vascular-glial function and causes sensorimotor impairments. Some degree of sensorimotor recovery subsequently occurs, yet the changes in neuro-vascular-glial function that are directly linked to this recovery are not well understood. Moreover, understanding and monitoring stroke recovery in humans using non-invasive imaging of cerebral hemodynamics [blood oxygenation level-dependent (BOLD);cerebral blood volume (CBV);cerebral blood flow (CBF)] is hampered by uncertainties about the relationship between neuro-vascular-glial unit signals and the recovery process. Our preliminary data, based on functional magnetic resonance imaging (fMRI) and optical imaging in an animal stroke model and fMRI in stroke patients, suggest a differential evolution in hemodynamic signals and the metabolic signal (cerebral metabolic rate of oxygen, CMRO2) during the period of sensorimotor recovery. The proposed project is aimed at characterizinisms that underlie the evolution in hemodynamic and metabolic changes during sensorimotor recovery. The proposed experiments in an animal stroke model and stroke patients are closely linked, and thereby will provide important insights into the evolution of stroke recovery on phenomenological and mechanistic levels. The results of this project will also identify non-invasive imaging biomarkers that correlate with underlying neuro-vascular-glial restoration and remodeling for use in monitoring stroke recovery and efficacy of potential therapeutic agents in patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB002066-20
Application #
7661360
Study Section
Medical Imaging Study Section (MEDI)
Program Officer
Liu, Guoying
Project Start
1988-07-01
Project End
2011-07-31
Budget Start
2009-08-01
Budget End
2011-07-31
Support Year
20
Fiscal Year
2009
Total Cost
$518,277
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Hari, Riitta; Baillet, Sylvain; Barnes, Gareth et al. (2018) IFCN-endorsed practical guidelines for clinical magnetoencephalography (MEG). Clin Neurophysiol 129:1720-1747
Baek, Kwangyeol; Shim, Woo Hyun; Jeong, Jaeseung et al. (2016) Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies. Brain Struct Funct 221:2801-15
Kwong, Kenneth K; Chan, Suk-tak (2015) Intranasal oxytocin and NSAIDs : Comment on: Oxytocin nasal spray in fibromyalgic patients (Rheumatol Int. 2014 Aug;34(8):1047-52.). Rheumatol Int 35:941-2
Huang, Shuning; Farrar, Christian T; Dai, Guangping et al. (2012) Dynamic monitoring of blood-brain barrier integrity using water exchange index (WEI) during mannitol and CO(2) challenges in mouse brain. NMR Biomed :
Bolar, D S; Rosen, B R; Sorensen, A G et al. (2011) QUantitative Imaging of eXtraction of oxygen and TIssue consumption (QUIXOTIC) using venular-targeted velocity-selective spin labeling. Magn Reson Med 66:1550-62
Devor, Anna; Sakadzic, Sava; Saisan, Payam A et al. (2011) ""Overshoot"" of O? is required to maintain baseline tissue oxygenation at locations distal to blood vessels. J Neurosci 31:13676-81
Kwong, Kenneth K; Chesler, David A (2011) Early time points perfusion imaging: theoretical analysis of correction factors for relative cerebral blood flow estimation given local arterial input function. Neuroimage 57:182-9
Kwong, Kenneth K; Wu, Ona; Chan, Suk-Tak et al. (2011) Early time points perfusion imaging: relative time of arrival, maximum derivatives and fractional derivatives. Neuroimage 57:979-90
Rosen, Bruce R; Napadow, Vitaly (2011) Quantitative markers for neuropsychiatric disease: give it a rest. Radiology 259:17-9
Eikermann-Haerter, Katharina; Yuzawa, Izumi; Qin, Tao et al. (2011) Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice. J Neurosci 31:5755-63

Showing the most recent 10 out of 24 publications