Abstract

This research proposal describes a program directed towards the total synthesis of two complex macrolide natural products: nystatin and halichondrin B. These compounds exhibit potent antifungal (nystatin) and antitumor activities (nystatin and halichondrin B).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM026879-09A1
Application #
3274336
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1979-09-01
Project End
1993-03-31
Budget Start
1988-04-01
Budget End
1989-03-31
Support Year
9
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104