Total Synthesis of Macrolides

Nicolaou, K. C.

Abstract

This research proposal describes a program directed towards the total synthesis of two complex macrolide natural products: nystatin and halichondrin B. These compounds exhibit potent antifungal (nystatin) and antitumor activities (nystatin and halichondrin B).

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Project (R01)
• Project #: 5R01GM026879-10
• Application #: 3274341
• Study Section: Medicinal Chemistry Study Section (MCHA)
• Project Start: 1979-09-01
• Project End: 1990-03-31
• Budget Start: 1989-04-01
• Budget End: 1990-03-31
• Support Year: 10
• Fiscal Year: 1989

Institution

• Name: University of Pennsylvania
• Type: Schools of Arts and Sciences
• DUNS #: 042250712
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19104