Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052106-02
Application #
2191013
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1995-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Ueda, Yoshihide; Okano, Masaki; Williams, Christine et al. (2006) Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development 133:1183-92
Dodge, Jonathan E; Okano, Masaki; Dick, Fred et al. (2005) Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization. J Biol Chem 280:17986-91
Sado, Takashi; Okano, Masaki; Li, En et al. (2004) De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation. Development 131:975-82
Dodge, Jonathan E; Kang, Yong-Kook; Beppu, Hideyuki et al. (2004) Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol 24:2478-86
Chen, Taiping; Li, En (2004) Structure and function of eukaryotic DNA methyltransferases. Curr Top Dev Biol 60:55-89
Chen, Taiping; Tsujimoto, Naomi; Li, En (2004) The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol Cell Biol 24:9048-58
Chen, Taiping; Ueda, Yoshihide; Dodge, Jonathan E et al. (2003) Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol 23:5594-605
Gribnau, Joost; Hochedlinger, Konrad; Hata, Ken et al. (2003) Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization. Genes Dev 17:759-73
Lehnertz, Bernhard; Ueda, Yoshihide; Derijck, Alwin A H A et al. (2003) Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol 13:1192-200
Dodge, Jonathan E; Ramsahoye, Bernard H; Wo, Z Galen et al. (2002) De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation. Gene 289:41-8

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