Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL053284-02
Application #
2231125
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1995-07-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Clark, Craig B; Zhang, Yi; Martin, Sean M et al. (2004) The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. Resuscitation 60:351-7
Zhang, Yi; Davies, Loyd R; Martin, Sean M et al. (2003) The nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP) increases free radical generation and degrades left ventricular function after myocardial ischemia-reperfusion. Resuscitation 59:345-52
Zhang, Yi; Davies, Loyd R; Martin, Sean M et al. (2003) Magnesium reduces free radical concentration and preserves left ventricular function after direct current shocks. Resuscitation 56:199-206
Zhang, Yi; Davies, Loyd R; Coddington, William J et al. (2003) Open-chest epicardial ""surgical"" defibrillation: biphasic versus monophasic waveform shocks. Pacing Clin Electrophysiol 26:711-8
Zhang, Yi; Ramabadran, R S; Boddicker, Kimberly A et al. (2003) Triphasic waveforms are superior to biphasic waveforms for transthoracic defibrillation: experimental studies. J Am Coll Cardiol 42:568-75
Clark, Craig B; Zhang, Yi; Martin, Sean M et al. (2003) The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. Resuscitation 57:101-8
Oltman, Christine L; Clark, Craig B; Kane, Neal L et al. (2003) Coronary vascular dysfunction associated with direct current shock injury. Basic Res Cardiol 98:406-15
Zhang, Yi; Clark, Craig B; Davies, L Ray et al. (2002) Body weight is a predictor of biphasic shock success for low energy transthoracic defibrillation. Resuscitation 54:281-7
Clark, Craig B; Zhang, Yi; Davies, L Ray et al. (2002) Transthoracic biphasic waveform defibrillation at very high and very low energies: a comparison with monophasic waveforms in an animal model of ventricular fibrillation. Resuscitation 54:183-6
Karlsson, G; Zhang, Y; Davies, L R et al. (2001) Does electrode polarity alter the energy requirements for transthoracic biphasic waveform defibrillation? Experimental studies. Resuscitation 51:77-81

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