Abstract

The primary focus of this project is to apply recent advances made in magnetic resonance imaging (MRI) and MR angiography (MRA) to the problem of accurate depiction and diagnosis of cervical carotid artery disease. The investigators have developed a special purpose 4 element phased array coil and a set of white blood and black blood imaging techniques which are optimized for yielding very high quality, high resolution images of the cervical carotid artery anatomy and flow. They believe that their high resolution imaging technique will provide the best measures of carotid disease significance. In this study, they will compare the accuracy of these high resolution MRI and MRA techniques in the depiction of the disease using the endarterectomy sample removed en bloc as the truth standard. They will test whether the relative measurements obtained from MRI and MRA are more accurate than x-ray angiography and duplex ultrasound in providing clinically significant measurements of stenosis and plaque burden. This study is configured to complement their involvement in the ACSCEPT protocol (Assessment of carotid stenosis by comparison with endarterectomy plaque trial) and increase the information to be obtained from this study. Patients studied as part of the ACSCEPT evaluation of standardized MRA techniques will also be enrolled in our study of high resolution MRA and MRA efficacy. The morphological measurements of lumen and plaque made from excised endarterectomy sample will be the truth standard for the high resolution techniques. Other surgical patients and non-surgical patients with documented disease will be followed with high resolution MRI and MRA to study the correlation of morphological findings with the onset of clinical symptoms. Although the primary focus of this study will be to assess the diagnostic efficacy of morphological measurements obtained from MRI/MRA, the work will also begin to assemble qualitative assessments of plaque appearance on the images and examine the correlation between those assessments and histological findings.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL057990-03
Application #
6151345
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1998-02-01
Project End
2002-01-31
Budget Start
2000-02-01
Budget End
2002-01-31
Support Year
3
Fiscal Year
2000
Total Cost
$257,666
Indirect Cost

  Institution

Name
University of Utah
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Kim, Seong-Eun; Roberts, John A; Eisenmenger, Laura B et al. (2017) Motion-insensitive carotid intraplaque hemorrhage imaging using 3D inversion recovery preparation stack of stars (IR-prep SOS) technique. J Magn Reson Imaging 45:410-417
Scott McNally, J; Yoon, Hyo-Chun; Kim, Seong-Eun et al. (2015) Carotid MRI Detection of Intraplaque Hemorrhage at 3T and 1.5T. J Neuroimaging 25:390-6
Mendes, Jason; Parker, Dennis L; McNally, Scott et al. (2014) Three-dimensional dynamic contrast enhanced imaging of the carotid artery with direct arterial input function measurement. Magn Reson Med 72:816-22
Hulet, Jordan P; Greiser, Andreas; Mendes, Jason K et al. (2014) Highly accelerated cardiac cine phase-contrast MRI using an undersampled radial acquisition and temporally constrained reconstruction. J Magn Reson Imaging 39:455-62
Mendes, Jason; Parker, Dennis L; Kim, Seong-Eun et al. (2013) Reduced blood flow artifact in intraplaque hemorrhage imaging using CineMPRAGE. Magn Reson Med 69:1276-84
Tate, Quinn; Kim, Seong-Eun; Treiman, Gerald et al. (2013) Increased vessel depiction of the carotid bifurcation with a specialized 16-channel phased array coil at 3T. Magn Reson Med 69:1486-93
McNally, J Scott; Kim, Seong-Eun; Yoon, Hyo-Chun et al. (2012) Carotid magnetization-prepared rapid acquisition with gradient-echo signal is associated with acute territorial cerebral ischemic events detected by diffusion-weighted MRI. Circ Cardiovasc Imaging 5:376-82
Park, J K; Kim, S-E; Trieman, G S et al. (2011) High-resolution diffusion-weighted imaging of neck lymph nodes using 2D-single-shot interleaved multiple inner volume imaging diffusion-weighted echo-planar imaging at 3T. AJNR Am J Neuroradiol 32:1173-7
Kim, Seong-Eun; Treiman, Gerald S; Roberts, John A et al. (2011) In vivo and ex vivo measurements of the mean ADC values of lipid necrotic core and hemorrhage obtained from diffusion weighted imaging in human atherosclerotic plaques. J Magn Reson Imaging 34:1167-75
Mendes, Jason; Parker, Dennis L (2011) Intrinsic detection of motion in segmented sequences. Magn Reson Med 65:1084-9

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