(Taken from project abstract): In the past two decades new imaging technology has given neurologists noninvasive tools which reveal the structure of the brain with a clarity that is little short of miraculous. At the same time, neuroscientists, often in animal studies, have developed ways to reveal hundreds of chemical and functional features of the brain that are relevant to human brain function. The problem of integrating new knowledge to the benefit of human patients is exploding in both magnitude and complexity. This project addresses that problem by developing a Brain Information Management System for knowledge obtained from human and non-human primate research. The system will allow the most precise possible indexation of written and pictorial information into a knowledge base that is accessible through the standard terminology of the National Library of Medicine's Unified Medical Language System. Clinicians and neuroscientists anywhere in the country will be able to access the system via the World Wide Web to determine what is known about the involvement of any brain structure with any of the characteristics described in the neuroscientific knowledge base. The system will be evaluated by using it to identify neural pathways in the primate brain that are likely to mediate the rewarding effects of electrical stimulation of the brain. The computerized Brain Information Management System is intended to accelerate the application of basic neuroscientific knowledge in the clinical discipline neurosurgery, neurology and neuropsychiatry. The research project used to test the system holds promise of better understanding of drug abuse, depression and dementia.

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Research Project (R01)
Project #
5R01LM006243-02
Application #
2519676
Study Section
Biomedical Library and Informatics Review Committee (BLR)
Project Start
1996-09-16
Project End
1999-08-31
Budget Start
1997-09-01
Budget End
1998-08-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Washington
Department
Veterinary Sciences
Type
Other Domestic Higher Education
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Bowden, Douglas M; Song, Evan; Kosheleva, Julia et al. (2012) NeuroNames: an ontology for the BrainInfo portal to neuroscience on the web. Neuroinformatics 10:97-114
Annese, J; Sforza, D M; Dubach, M et al. (2006) Postmortem high-resolution 3-dimensional imaging of the primate brain: blockface imaging of perfusion stained tissue. Neuroimage 30:61-9
Bowden, Douglas M; Dubach, Mark F (2003) NeuroNames 2002. Neuroinformatics 1:43-59
Kumar, P A; Baker, L P; Storm, D R et al. (2001) Expression of type I adenylyl cyclase in intrinsic pathways of the hippocampal formation of the macaque (Macaca nemestrina). Neurosci Lett 299:181-4