Schizophrenia has resisted generic rehabilitation services designed to achieve a more complete social and vocational life. Cognitive remediation has been heralded as a more promising intervention. However, efforts to date have had variable results, with problems traced to: the cognitive deficits targeted and remediation methods used; failures to truly integrate elementary deficit and social cognitive training; an exclusive emphasis on more cognitively compromised inpatients; a relative de-emphasis of individual programming; and the inclusion of briefly treated, small samples that have lacked the requisite statistical power needed to detect treatment effects. In an individually tailored and personally meaningful approach that integrates elementary deficit and social cognitive training, Cognitive Enhancement Therapy attempts to develop a more abstracting social cognition related to perspective taking and the appraisal of informal rules that govern changing social contexts, (the apparent sources of schizophrenic disability), among recovering outpatients. It does so by adapting the methods and procedures of successful programs for the traumatic brain injured to the impairments, disabilities and handicaps of the Disorganized, Impoverished and Rigid cognitive styles common in schizophrenia. In a 2 year, randomized contrast to an Enriched Supportive Therapy, CET is predicted to differentially improve social cognition, with associated gains in the areas of interpersonal and vocational effectiveness, self-esteem, neuropsychological competence and residual symptoms. Support is requested to complete the ongoing study for 100 of the 150 patients who will be in protocol between 1/97 and 6/01.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH030750-24
Application #
6185920
Study Section
Treatment Assessment Review Committee (TA)
Program Officer
Niederehe, George T
Project Start
1978-04-01
Project End
2002-04-30
Budget Start
2000-05-01
Budget End
2002-04-30
Support Year
24
Fiscal Year
2000
Total Cost
$844,092
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Hogarty, Gerard E; Greenwald, Deborah P; Eack, Shaun M (2006) Durability and mechanism of effects of cognitive enhancement therapy. Psychiatr Serv 57:1751-7
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Hogarty, G E; Kornblith, S J; Greenwald, D et al. (1997) Three-year trials of personal therapy among schizophrenic patients living with or independent of family, I: Description of study and effects on relapse rates. Am J Psychiatry 154:1504-13
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Hogarty, G E; Anderson, C M; Reiss, D J et al. (1991) Family psychoeducation, social skills training, and maintenance chemotherapy in the aftercare treatment of schizophrenia. II. Two-year effects of a controlled study on relapse and adjustment. Environmental-Personal Indicators in the Course of Schizophreni Arch Gen Psychiatry 48:340-7
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