Until recently, it was believed that multisensory integration begins in high-level cortical regions, after protracted hierarchical processing within each unisensory system. Results in the prior project period refute this view. The hypothesis driving our competing renewal application incorporates low-level multisensory processing with that occurring in higher-order multisensory regions. The pervasiveness of low-level integrative operations is staggering. Among recent findings showing direct anatomical connections between A1 and V1, and a wealth of low-level influences on auditory processing, is the remarkable ability of non-auditory inputs to control the pattern of ongoing neuronal activity in auditory cortex. This is fundamentally significant because ongoing neuronal activity sets the context within which incoming sensory inputs are processed. Our preliminary data make several key predictions about the manner in which context is controlled, and about the way that it in turn controls sensory processing. Our long-term goal is to define the mechanisms of multisensory interactions in auditory cortex, and their contributions to the auditory functions of the region.
Our specific aims are: 1. To consolidate and extend our understanding of the functional properties, areal distribution and anatomical mechanisms of visual, as well as somatosensory inputs in auditory cortex. 2. To determine how ongoing oscillatory dynamics control the both unisensory (e.g., auditory) and multisensory integration in auditory cortex. 3. To investigate how auditory cortical dynamics are addressed by attention and discrimination. Because of our unique combination of methods we can bridge the gap between incisive findings from in-vitro cellular-level experiments and effects noted by electromagnetic and hemodynamic imaging studies in humans.
| Lakatos, Peter; Schroeder, Charles E; Leitman, David I et al. (2013) Predictive suppression of cortical excitability and its deficit in schizophrenia. J Neurosci 33:11692-702 |
| O'Connell, Monica N; Falchier, Arnaud; McGinnis, Tammy et al. (2011) Dual mechanism of neuronal ensemble inhibition in primary auditory cortex. Neuron 69:805-17 |
| Schroeder, Charles E; Wilson, Donald A; Radman, Thomas et al. (2010) Dynamics of Active Sensing and perceptual selection. Curr Opin Neurobiol 20:172-6 |
| Falchier, Arnaud; Schroeder, Charles E; Hackett, Troy A et al. (2010) Projection from visual areas V2 and prostriata to caudal auditory cortex in the monkey. Cereb Cortex 20:1529-38 |
| Schroeder, Charles E; Lakatos, Peter (2009) Low-frequency neuronal oscillations as instruments of sensory selection. Trends Neurosci 32:9-18 |
| Musacchia, Gabriella; Schroeder, Charles E (2009) Neuronal mechanisms, response dynamics and perceptual functions of multisensory interactions in auditory cortex. Hear Res 258:72-9 |
| Lakatos, Peter; O'Connell, Monica N; Barczak, Annamaria et al. (2009) The leading sense: supramodal control of neurophysiological context by attention. Neuron 64:419-30 |
| Smiley, John F; Falchier, Arnaud (2009) Multisensory connections of monkey auditory cerebral cortex. Hear Res 258:37-46 |
| Schroeder, Charles E; Lakatos, Peter; Kajikawa, Yoshinao et al. (2008) Neuronal oscillations and visual amplification of speech. Trends Cogn Sci 12:106-13 |
| Hackett, Troy A; De La Mothe, Lisa A; Ulbert, Istvan et al. (2007) Multisensory convergence in auditory cortex, II. Thalamocortical connections of the caudal superior temporal plane. J Comp Neurol 502:924-52 |
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