The investigators propose to expand upon a preliminary finding that one or more regions of classic auditory association cortex posterior to A1 are sites of multisensory convergence, in that they respond to somatosensory stimuli, as well as sounds. This surprising finding disputes a prevailing view that multisensory integration is confined to specialized, higher order """"""""association"""""""" structures. It also bears on the fundamental question of whether auditory and somatosensory systems have """"""""what"""""""" and """"""""where"""""""" divisions like those proposed for the visual pathways. Anatomical tracer studies, in conjunction with standard multiunit / single unit mapping procedures in anesthetized monkeys and with multielectrode studies in awake monkeys will address 3 specific aims. 1) To delineate the somatosensory map(s) and determine of the relationship of somatosensory representation to previously defined auditory fields. 2) To identify the anatomical source(s) of somatosensory input. 3) To determine the functional significance of auditory-somatosensory co-representation. These experiments will evaluate the hypotheses that the caudal belt and parabelt regions of auditory cortex are involved in auditory localization and that somatosensory-auditory interactions contribute to this function.
| Lakatos, Peter; Schroeder, Charles E; Leitman, David I et al. (2013) Predictive suppression of cortical excitability and its deficit in schizophrenia. J Neurosci 33:11692-702 |
| O'Connell, Monica N; Falchier, Arnaud; McGinnis, Tammy et al. (2011) Dual mechanism of neuronal ensemble inhibition in primary auditory cortex. Neuron 69:805-17 |
| Schroeder, Charles E; Wilson, Donald A; Radman, Thomas et al. (2010) Dynamics of Active Sensing and perceptual selection. Curr Opin Neurobiol 20:172-6 |
| Falchier, Arnaud; Schroeder, Charles E; Hackett, Troy A et al. (2010) Projection from visual areas V2 and prostriata to caudal auditory cortex in the monkey. Cereb Cortex 20:1529-38 |
| Schroeder, Charles E; Lakatos, Peter (2009) Low-frequency neuronal oscillations as instruments of sensory selection. Trends Neurosci 32:9-18 |
| Musacchia, Gabriella; Schroeder, Charles E (2009) Neuronal mechanisms, response dynamics and perceptual functions of multisensory interactions in auditory cortex. Hear Res 258:72-9 |
| Lakatos, Peter; O'Connell, Monica N; Barczak, Annamaria et al. (2009) The leading sense: supramodal control of neurophysiological context by attention. Neuron 64:419-30 |
| Smiley, John F; Falchier, Arnaud (2009) Multisensory connections of monkey auditory cerebral cortex. Hear Res 258:37-46 |
| Schroeder, Charles E; Lakatos, Peter; Kajikawa, Yoshinao et al. (2008) Neuronal oscillations and visual amplification of speech. Trends Cogn Sci 12:106-13 |
| Hackett, Troy A; De La Mothe, Lisa A; Ulbert, Istvan et al. (2007) Multisensory convergence in auditory cortex, II. Thalamocortical connections of the caudal superior temporal plane. J Comp Neurol 502:924-52 |
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