Abstract

The general objective of this work is to investigate the physiology and biophysics of cochlear transducer processes. Within this framework the efforts are concentrated on the delineation of the properties and function of stimulus-related cochlear potentials, and on the assessment of the role of the two receptor cell populations, inner and outer hair cells. These goals are pursued by a combined application of physiological (gross potential recording, single hair cell recording, and single nerve fiber recording), behavioral and histological measurements.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS008635-18
Application #
3393790
Study Section
Hearing Research Study Section (HAR)
Project Start
1979-01-01
Project End
1990-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
18
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Type
Schools of Arts and Sciences
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60208

  Publications

Siegel, J H (1992) Spontaneous synaptic potentials from afferent terminals in the guinea pig cochlea. Hear Res 59:85-92
Ohlemiller, K K; Echteler, S M; Siegel, J H (1991) Factors that influence rate-versus-intensity relations in single cochlear nerve fibers of the gerbil. J Acoust Soc Am 90:274-87
Evans, B N (1990) Fatal contractions: ultrastructural and electromechanical changes in outer hair cells following transmembraneous electrical stimulation. Hear Res 45:265-82
Ohlemiller, K K; Echteler, S M (1990) Functional correlates of characteristic frequency in single cochlear nerve fibers of the Mongolian gerbil. J Comp Physiol A 167:329-38
Cheatham, M A; Dallos, P (1990) Two-tone interactions in inner hair cell receptor potentials: AC versus DC effects. Hear Res 43:135-9
Dallos, P; Cheatham, M A (1990) Effects of electrical polarization on inner hair cell receptor potentials. J Acoust Soc Am 87:1636-47
Oesterle, E C; Dallos, P (1990) Intracellular recordings from supporting cells in the guinea pig cochlea: DC potentials. J Neurophysiol 64:617-36
Warchol, M E; Dallos, P (1990) Neural coding in the chick cochlear nucleus. J Comp Physiol A 166:721-34
Cheatham, M A; Dallos, P (1990) Comparison of low- and high-side two-tone suppression in inner hair cell and organ of Corti responses. Hear Res 50:193-209
Clark, B A; Hallworth, R; Evans, B N (1990) Calibration of photodiode measurements of cell motion by a transmission optical lever method. Pflugers Arch 415:490-3

Showing the most recent 10 out of 28 publications