Pharmacokinetics and Metabolism of Gliomas

Feindel, William

Abstract

Radiolabelling of BCNU by C-11 or N-13 has provided a means of mapping, with PET sequential scans, the entry, distribution, and persistence of this drug in Grade III and IV human gliomas. Our preliminary findings indicate that the differential uptake of the drug is greater in the tumor than in a control area of brain, and that it also has a different clearance half-life. PET mapping following supra-selective intracerebral arterial infusion of BCNU has shown significant reduction, and in one case almost total disappearance of the tumor. More detailed studies using PET and experimental radioautography of radio-labelled BCNU, AspCNU, and SarCNU will be made. The resulting information would improve the scientific basis and methodology of administration of drugs now available. It would also provide a model for evaluating new drugs. The metabolic information derived from PET scanning of gliomas would help to correlate these chemical and biological activity and provide a means of early detection of tumor response to chemotherapy and radiotherapy.

Funding Agency

Agency: National Institute of Health (NIH)
Institute: National Institute of Neurological Disorders and Stroke (NINDS)
Type: Research Project (R01)
Project #: 1R01NS022230-01A1
Application #: 3404405
Study Section: Neurology A Study Section (NEUA)

Project Start: 1986-01-01
Project End: 1988-12-31
Budget Start: 1986-01-01
Budget End: 1986-12-31
Support Year: 1
Fiscal Year: 1986
Total Cost
Indirect Cost

Institution

Name: Mcgill University
Department
Type
DUNS #

City: Montreal
State: PQ
Country: Canada
Zip Code: H3 2T5

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NIH 1995 R01 NS	Mechanism of Increased Cytotoxicity of Sarcnu in Gliomas Panasci, Lawrence C. / Sir Mortimer B. Davis Jewish Gen Hosp
NIH 1994 R01 NS	Mechanism of Increased Cytotoxicity of Sarcnu in Gliomas Panasci, Lawrence C. / Sir Mortimer B. Davis Jewish Gen Hosp
NIH 1992 R01 NS	Mechanism of Increased Cytotoxicity of Sarcnu in Gliomas Panasci, Lawrence C. / Mcgill University
NIH 1991 R01 NS	Mechanism of Increased Cytotoxicity of Sarcnu in Gliomas Panasci, Lawrence C. / Mcgill University
NIH 1990 R01 NS	Mechanism of Increased Cytotoxicity of Sarcnu in Gliomas Panasci, Lawrence C. / Mcgill University
NIH 1989 R01 NS	Pharmacokinetics and Metabolism of Gliomas Feindel, William H. / Mcgill University
NIH 1988 R01 NS	Pharmacokinetics and Metabolism of Gliomas Feindel, William H. / Mcgill University
NIH 1987 R01 NS	Pharmacokinetics and Metabolism of Gliomas Feindel, William H. / Mcgill University
NIH 1986 R01 NS	Pharmacokinetics and Metabolism of Gliomas Feindel, William H. / Mcgill University