Radiolabelling of BCNU by C-11 or N-13 has provided a means of mapping, with PET sequential scans, the entry, distribution, and persistence of this drug in Grade III and IV human gliomas. Our preliminary findings indicate that the differential uptake of the drug is greater in the tumor than in a control area of brain, and that it also has a different clearance half-life. PET mapping following supra-selective intracerebral arterial infusion of BCNU has shown significant reduction, and in one case almost total disappearance of the tumor. More detailed studies using PET and experimental radioautography of radio-labelled BCNU, AspCNU, and SarCNU will be made. The resulting information would improve the scientific basis and methodology of administration of drugs now available. It would also provide a model for evaluating new drugs. The metabolic information derived from PET scanning of gliomas would help to correlate these chemical and biological activity and provide a means of early detection of tumor response to chemotherapy and radiotherapy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS022230-03
Application #
3404413
Study Section
Neurology A Study Section (NEUA)
Project Start
1986-01-01
Project End
1989-02-28
Budget Start
1988-01-01
Budget End
1989-02-28
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Mcgill University
Department
Type
DUNS #
City
Montreal
State
PQ
Country
Canada
Zip Code
H3 2T5
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Bramson, J; O'Connor, T; Panasci, L (1995) Effect of alkyl-N-purine DNA glycosylase overexpression on cellular resistance to bifunctional alkylating agents. Biochem Pharmacol 50:39-44
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