The corpus striatum (caudate nucleus, putamen, and globus pallidus) plays an important role in coordinating and patterning movement. Damage to the striatum in humans, such as occurs in Huntington's chorea in Parkinson's or Wilson's diseases, produces profound and complex behavioral disruptions. Current hypotheses of striatal function have suggested the corpus striatum patterns action by contributing to (a) the initiation and execution of centrally-programmed (""""""""player-piano"""""""") sequences of behavior and/or (b) the modulation of sensorimotor processing so as to bring feedback-guided action under control of appropriate stimuli. To study such complex sequencing or senorimotor function, one requires behavioral dependent variables that contain both centrally-programmed and sensory-guided features. The form and sequence of natural actions used by rats in feeding and grooming have been previously shown to possess identifiable features of both types, and to be well suited to investigation of the neural mechanisms of behavior. The proposed studies employ a set of sensitive ethological measures of behavioral form and sequence to ascertain the effect of striatal lesions and striatal stimulation upon the use of sensory information and central programs to guide action. The results of these studies should help clarify the role of the corpus striatum in guiding behavior. A second goal of the proposed studies is to identify the trigger of a lesion-induced chorea, which preliminary studies have shown to occur under specific conditions. We will also ascertain whether the anti-choreatic agent, haloperidol, can suppress this chorea. The results of this second focus may provide a useful nonprimate model of mechanisms of behavioral chorea.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS023959-03
Application #
3408098
Study Section
Biopsychology Study Section (BPO)
Project Start
1986-08-01
Project End
1989-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Arts and Sciences
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Cromwell, H C; Berridge, K C (1997) Haloperidol decreases hyperkinetic paw treading induced by globus pallidus lesions in the rat. Exp Neurol 145:288-94
Cromwell, H C; Berridge, K C (1996) Implementation of action sequences by a neostriatal site: a lesion mapping study of grooming syntax. J Neurosci 16:3444-58
Cromwell, H C; Berridge, K C (1994) Mapping of globus pallidus and ventral pallidum lesions that produce hyperkinetic treading. Brain Res 668:16-29
Robinson, T E; Berridge, K C (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247-91
Doyle, T G; Berridge, K C; Gosnell, B A (1993) Morphine enhances hedonic taste palatability in rats. Pharmacol Biochem Behav 46:745-9
Cromwell, H C; Berridge, K C (1993) Where does damage lead to enhanced food aversion: the ventral pallidum/substantia innominata or lateral hypothalamus? Brain Res 624:1-10
Berridge, K C; Whishaw, I Q (1992) Cortex, striatum and cerebellum: control of serial order in a grooming sequence. Exp Brain Res 90:275-90
Berridge, K C; Valenstein, E S (1991) What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus? Behav Neurosci 105:3-14
Berridge, K C (1991) Modulation of taste affect by hunger, caloric satiety, and sensory-specific satiety in the rat. Appetite 16:103-20
Berridge, K C; Cromwell, H C (1990) Motivational-sensorimotor interaction controls aphagia and exaggerated treading after striatopallidal lesions. Behav Neurosci 104:778-95

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