Natural action is sequentially coordinated. It is characterized by complex and pervasive patterns or rules, which organize the connections of elemental movements into effective behavioral sequences. Implementation of such patterning rules by the brain is crucial to normal behavior. When damage to striatal or related brain structures involved in sequential patterning and in high level sensorimotor integration occurs in human Huntington's or Parkinson's disease, enormous behavioral disruption results. Equivalent disruption in the patterning of natural behavior in animals can be produced by analogous brain damage. This proposal uses patterns of natural species-specific action structure to examine how striatal circuits carry out their behavioral sequencing and high-level integration functions. in particular, these experiments will: a) specify striatal subregions and neurotransmitter systems crucial to natural sequencing and sensorimotor function, b) identify the role of sensory-to-motor linkage modulation in the striatal control of behavioral sequencing, and c) examine the gating role of motivational factors in the control of a choreic sensorimotor pathology that is produced by striatopallidal lesions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS023959-04
Application #
3408093
Study Section
Biopsychology Study Section (BPO)
Project Start
1989-08-01
Project End
1992-07-31
Budget Start
1989-08-01
Budget End
1990-07-31
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Arts and Sciences
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Cromwell, H C; Berridge, K C (1997) Haloperidol decreases hyperkinetic paw treading induced by globus pallidus lesions in the rat. Exp Neurol 145:288-94
Cromwell, H C; Berridge, K C (1996) Implementation of action sequences by a neostriatal site: a lesion mapping study of grooming syntax. J Neurosci 16:3444-58
Cromwell, H C; Berridge, K C (1994) Mapping of globus pallidus and ventral pallidum lesions that produce hyperkinetic treading. Brain Res 668:16-29
Robinson, T E; Berridge, K C (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247-91
Doyle, T G; Berridge, K C; Gosnell, B A (1993) Morphine enhances hedonic taste palatability in rats. Pharmacol Biochem Behav 46:745-9
Cromwell, H C; Berridge, K C (1993) Where does damage lead to enhanced food aversion: the ventral pallidum/substantia innominata or lateral hypothalamus? Brain Res 624:1-10
Berridge, K C; Whishaw, I Q (1992) Cortex, striatum and cerebellum: control of serial order in a grooming sequence. Exp Brain Res 90:275-90
Berridge, K C (1991) Modulation of taste affect by hunger, caloric satiety, and sensory-specific satiety in the rat. Appetite 16:103-20
Berridge, K C; Valenstein, E S (1991) What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus? Behav Neurosci 105:3-14
Berridge, K C; Cromwell, H C (1990) Motivational-sensorimotor interaction controls aphagia and exaggerated treading after striatopallidal lesions. Behav Neurosci 104:778-95

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