Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS030457-04
Application #
2268421
Study Section
Special Emphasis Panel (SRC (33))
Project Start
1991-09-30
Project End
1997-09-29
Budget Start
1994-09-30
Budget End
1997-09-29
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Pathology
Type
Schools of Dentistry
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Grammas, P; Moore, P; Weigel, P H (1999) Microvessels from Alzheimer's disease brains kill neurons in vitro. Am J Pathol 154:337-42
Moore, P; White, J; Christiansen, V et al. (1998) Protein kinase C-zeta activity but not level is decreased in Alzheimer's disease microvessels. Neurosci Lett 254:29-32
Grammas, P; Moore, P; Cashman, R E et al. (1998) Anoxic injury of endothelial cells causes divergent changes in protein kinase C and protein kinase A signaling pathways. Mol Chem Neuropathol 33:113-24
Delton-Vandenbroucke, I; Grammas, P; Anderson, R E (1998) Regulation of n-3 and n-6 fatty acid metabolism in retinal and cerebral microvascular endothelial cells by high glucose. J Neurochem 70:841-9
Grammas, P; Botchlet, T R; Moore, P et al. (1997) Production of neurotoxic factors by brain endothelium in Alzheimer's disease. Ann N Y Acad Sci 826:47-55
Delton-Vandenbroucke, I; Grammas, P; Anderson, R E (1997) Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells. J Lipid Res 38:147-59
Kumar, M; Liu, G J; Floyd, R A et al. (1996) Anoxic injury of endothelial cells increases production of nitric oxide and hydroxyl radicals. Biochem Biophys Res Commun 219:497-501
Kumar, M; Grammas, P; Giacomelli, F et al. (1996) Selective expression of c-mas proto-oncogene in rat cerebral endothelial cells. Neuroreport 8:93-6
Pereira, H A; Kumar, P; Grammas, P (1996) Expression of CAP37, a novel inflammatory mediator, in Alzheimer's disease. Neurobiol Aging 17:753-9
Pereira, H A; Moore, P; Grammas, P (1996) CAP37, a neutrophil granule-derived protein stimulates protein kinase C activity in endothelial cells. J Leukoc Biol 60:415-22

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