Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK044440-05
Application #
2143789
Study Section
General Medicine B Study Section (GMB)
Project Start
1992-02-01
Project End
1997-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Utah
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Michael, J R; Markewitz, B A; Kohan, D E (1997) Oxidant stress regulates basal endothelin-1 production by cultured rat pulmonary endothelial cells. Am J Physiol 273:L768-74
Markewitz, B A; Michael, J R; Kohan, D E (1997) Endothelin-1 inhibits the expression of inducible nitric oxide synthase. Am J Physiol 272:L1078-83
Kohan, D E (1997) Endothelins in the normal and diseased kidney. Am J Kidney Dis 29:2-26
Kohan, D E (1996) Endothelins: renal tubule synthesis and actions. Clin Exp Pharmacol Physiol 23:337-44
Hughes, A K; Stricklett, P K; Padilla, E et al. (1996) Effect of reactive oxygen species on endothelin-1 production by human mesangial cells. Kidney Int 49:181-9
Hughes, A K; Barry, W H; Kohan, D E (1995) Identification of a contractile function for renal medullary interstitial cells. J Clin Invest 96:411-6
Markewitz, B A; Kohan, D E; Michael, J R (1995) Endothelin-1 synthesis, receptors, and signal transduction in alveolar epithelium: evidence for an autocrine role. Am J Physiol 268:L192-200
Markewitz, B A; Kohan, D E; Michael, J R (1995) Hypoxia decreases endothelin-1 synthesis by rat lung endothelial cells. Am J Physiol 269:L215-20
Hughes, A K; Padilla, E; Kutchera, W A et al. (1995) Endothelin-1 induction of cyclooxygenase-2 expression in rat mesangial cells. Kidney Int 47:53-61
Markewitz, B A; Kohan, D E (1995) Role of intrarenal endothelin in the generation and maintenance of hypertension. Miner Electrolyte Metab 21:342-52

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