Abstract

Diana Arguijo has a unique background with a double major in biomedical engineering (BME) and electrical and computer engineering (ECE). Leveraging her strong mathematical background, she will develop computational techniques to identify patterns of epigenetic reprogramming during epithelial development and patterns of real- time electrical recoding of the GI tract reflective of sacral nerve modulation. Her work will provide insights into the robustness and plasticity of underlying biological control schemes.

Public Health Relevance

Diana Arguijo will develop machine-learning based computational techniques to analyze epigenetic reprogramming of epithelial development and electrical activities of the enteric nervous system. Her analyses will provide insights into the robustness and plasticity of tissue regulation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Unknown (R35)
Project #
3R35GM122465-02S1
Application #
9731853
Study Section
Program Officer
Gibbs, Kenneth D
Project Start
2017-04-01
Project End
2022-03-31
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Biomedical Engineering
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Bu, Pengcheng; Chen, Kai-Yuan; Xiang, Kun et al. (2018) Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metab 27:1249-1262.e4
Chen, Kai-Yuan; Srinivasan, Tara; Lin, Christopher et al. (2018) Single-Cell Transcriptomics Reveals Heterogeneity and Drug Response of Human Colorectal Cancer Organoids. Conf Proc IEEE Eng Med Biol Soc 2018:2378-2381
Kadur Lakshminarasimha Murthy, Preetish; Srinivasan, Tara; Bochter, Matthew S et al. (2018) Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis. Elife 7:
Chen, Kai-Yuan; Shen, Xiling; Diehl, Anna Mae (2018) Prometheus revisited. J Clin Invest 128:2192-2193
Chen, Kai-Yuan; Srinivasan, Tara; Tung, Kuei-Ling et al. (2017) A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. Mol Syst Biol 13:927
Klose, Christoph S N; Mahlakõiv, Tanel; Moeller, Jesper B et al. (2017) The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation. Nature 549:282-286
Barth, Bradley B; Henriquez, Craig S; Grill, Warren M et al. (2017) Electrical stimulation of gut motility guided by an in silico model. J Neural Eng 14:066010