Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37DK039520-17
Application #
6605224
Study Section
Special Emphasis Panel (NSS)
Program Officer
Haft, Carol R
Project Start
1995-02-11
Project End
2008-01-31
Budget Start
2003-02-01
Budget End
2004-01-31
Support Year
17
Fiscal Year
2003
Total Cost
$593,820
Indirect Cost
Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
009584210
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Oh, Jang-Hyun; Hyun, Ju-Yeon; Varshavsky, Alexander (2017) Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway. Proc Natl Acad Sci U S A 114:E4370-E4379
Piatkov, Konstantin I; Vu, Tri T M; Hwang, Cheol-Sang et al. (2015) Formyl-methionine as a degradation signal at the N-termini of bacterial proteins. Microb Cell 2:376-393
Park, Sang-Eun; Kim, Jeong-Mok; Seok, Ok-Hee et al. (2015) Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway. Science 347:1249-1252
Piatkov, Konstantin I; Oh, Jang-Hyun; Liu, Yuan et al. (2014) Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway. Proc Natl Acad Sci U S A 111:E817-26
Brower, Christopher S; Rosen, Connor E; Jones, Richard H et al. (2014) Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats. Proc Natl Acad Sci U S A 111:E4936-45
Kim, Heon-Ki; Kim, Ryu-Ryun; Oh, Jang-Hyun et al. (2014) The N-terminal methionine of cellular proteins as a degradation signal. Cell 156:158-69
Piatkov, Konstantin; Graciet, Emmanuelle; Varshavsky, Alexander (2013) Ubiquitin reference technique and its use in ubiquitin-lacking prokaryotes. PLoS One 8:e67952
Brower, Christopher S; Piatkov, Konstantin I; Varshavsky, Alexander (2013) Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway. Mol Cell 50:161-71
Shemorry, Anna; Hwang, Cheol-Sang; Varshavsky, Alexander (2013) Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Mol Cell 50:540-51
Varshavsky, Alexander (2012) Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis. Protein Sci 21:1634-61

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