Abstract

This application proposes participation in the NIIMH cooperative agreement to establish Diagnostic Centers for Psychiatric Linkage Studies. In particular, it proposes participation in family studies of schizophrenia. Specifically, 66 families in which at least two sibs are diagnosed as schizophrenic according to DSM-IIIR criteria will be studied during years 2-4 of the proposed five year award. This application has several special strengths. It would be complemented and sponsored by an NIMH Clinical Research Center in psychiatric genetics. The principal investigators have extensive experience in the diagnosis and inheritance of schizophrenia, as well as the design and execution of linkage studies. The expertise of the investigators in psychiatric genetics in general, and schizophrenia in particular, would be useful to the proposed cooperative agreement between NIMH and several extramural sites.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01MH046276-04
Application #
3553891
Study Section
Special Emphasis Panel (SRCM (10))
Project Start
1989-09-30
Project End
1994-08-31
Budget Start
1992-09-15
Budget End
1993-08-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Kos, Mark Z; Duan, Jubao; Sanders, Alan R et al. (2018) Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery. Transl Psychiatry 8:278
(2018) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet 50:668-681
Duan, Jubao; Göring, Harald H H; Sanders, Alan R et al. (2018) Transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model. Transl Psychiatry 8:158
Sanders, A R; Drigalenko, E I; Duan, J et al. (2017) Transcriptome sequencing study implicates immune-related genes differentially expressed in schizophrenia: new data and a meta-analysis. Transl Psychiatry 7:e1093
Sanders, Alan R; Beecham, Gary W; Guo, Shengru et al. (2017) Genome-Wide Association Study of Male Sexual Orientation. Sci Rep 7:16950
Liu, C; Bousman, C A; Pantelis, C et al. (2017) Pathway-wide association study identifies five shared pathways associated with schizophrenia in three ancestral distinct populations. Transl Psychiatry 7:e1037
Franke, Barbara; Stein, Jason L; Ripke, Stephan et al. (2016) Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nat Neurosci 19:420-431
Zuo, Lingjun; Tan, Yunlong; Li, Chiang-Shan R et al. (2016) Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 171:1057-1071
Lee, Minyoung; Aggen, Steven H; Otowa, Takeshi et al. (2016) Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts. Int J Methods Psychiatr Res 25:255-266
Johnson, Eric O; Hancock, Dana B; Levy, Joshua L et al. (2016) KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. Addict Biol 21:1217-1232

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