Abstract

This proposal requests renewal for 3 years of a collaborative agreement between NIMH and extramural site at Columbia, Harvard, and Washington Universities to collect diagnostic information and DNA on individuals in pedigrees containing two or more schizophrenics. We propose to complete the extension of 108 pedigrees and to ascertain an additional 54 multiplex schizophrenia pedigrees, thereby providing information on about 400 schizophrenics and 950 non- schizophrenics in 162 pedigrees. This includes information on about 450 individuals in 54 families at each of the three collaborating sites. These pedigrees are systematically ascertained through two core schizophrenic and extended according to explicit rules.They will contain about 200 pairs of schizophrenic siblings. Simulation studies of power to detect linkage and amount of linkage information in the proposed sample indicate the feasibility of detecting linkage and mapping susceptibility loci if 25 percent or more of the cases of schizophrenia are attributable to variation in a single gene or a small number of epistatically interacting loci.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01MH046276-07
Application #
2246978
Study Section
Special Emphasis Panel (SRCM (03))
Project Start
1989-09-30
Project End
1997-08-31
Budget Start
1995-09-30
Budget End
1996-08-31
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Kos, Mark Z; Duan, Jubao; Sanders, Alan R et al. (2018) Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery. Transl Psychiatry 8:278
(2018) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet 50:668-681
Duan, Jubao; Göring, Harald H H; Sanders, Alan R et al. (2018) Transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model. Transl Psychiatry 8:158
Sanders, A R; Drigalenko, E I; Duan, J et al. (2017) Transcriptome sequencing study implicates immune-related genes differentially expressed in schizophrenia: new data and a meta-analysis. Transl Psychiatry 7:e1093
Sanders, Alan R; Beecham, Gary W; Guo, Shengru et al. (2017) Genome-Wide Association Study of Male Sexual Orientation. Sci Rep 7:16950
Liu, C; Bousman, C A; Pantelis, C et al. (2017) Pathway-wide association study identifies five shared pathways associated with schizophrenia in three ancestral distinct populations. Transl Psychiatry 7:e1037
Franke, Barbara; Stein, Jason L; Ripke, Stephan et al. (2016) Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nat Neurosci 19:420-431
Zuo, Lingjun; Tan, Yunlong; Li, Chiang-Shan R et al. (2016) Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 171:1057-1071
Lee, Minyoung; Aggen, Steven H; Otowa, Takeshi et al. (2016) Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts. Int J Methods Psychiatr Res 25:255-266
Johnson, Eric O; Hancock, Dana B; Levy, Joshua L et al. (2016) KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. Addict Biol 21:1217-1232

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