Virginia Commonwealth University (VCU) seeks funding for an Institutional Clinical and Translational Science Award (CTSA). This opportunity comes at a pivotal phase in VCU's growth and development as a premier biomedical research institution and coincides with significant institutional commitment and direction recommended by the Board of Visitors. To accomplish the goals ofthe CTSA initiative, VCU has established a comprehensive matrix center, the Center for Clinical and Translational Research (CCTR). The CCTR will facilitate the development of new partnerships and new initiatives that will extend our research base of fed- eral, private, and industry sponsored awards. Our already strong research program will be encouraged and abetted by a cultural transformation to support translational science and an influx of newly recruited multi- disciplinary investigators. The CCTR leverages substantial existing resources to encourage and support novel research methodologies at VCU. Emphasis is placed on three areas of research strength; namely substance abuse, women's health and rehabilitation science. Pilot funds will be awarded to support innova- tion and community engagement research in these areas. Architecture for a Clinical and Translational Data Environment, an enterprise data warehouse, and a collaborative web portal to facilitate data sharing across VCU, VCU Health System (VCUHS), other CTSA sites and national research networks has been developed A Research Incubator provides biostatistical support, facilitates research, encourages research in research ethics and provides guidance in regulatory issues. Strategies to enhance research subject participation, facilities for the conduction of human research, and access to the Mid-Atlantic Twin Registry are described. Centralized management of and access to a rich array of research resources will be accomplished through the CCTR. Our students will enroll in trans-disciplinary educational cumcula which encourage team building including both a MS and a PhD in Clinical and Translational Science. CCTR will strengthen ties with our affiliates and community partners to make better use of their unique resources and respond to their needs.

Public Health Relevance

Effective delivery of research which moves from the bench to the bedside to the community requires a transformation of research practice at every level. The present grant will support the efforts of VCU to strengthen ties with our affiliates and community partners to make better use of their unique resources and respond to their needs.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR000058-05S2
Application #
9031834
Study Section
Special Emphasis Panel (ZRR1-CR-1 (02))
Program Officer
Sufian, Meryl
Project Start
2010-07-01
Project End
2016-03-31
Budget Start
2015-04-01
Budget End
2016-03-31
Support Year
5
Fiscal Year
2015
Total Cost
$2,158,928
Indirect Cost
Name
Virginia Commonwealth University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Sonnenschein, Halie A; Lawrence, Kenneth F; Wittenberg, Karli A et al. (2018) Suppressor of IKKepsilon forms direct interactions with cytoskeletal proteins, tubulin and ?-actinin, linking innate immunity to the cytoskeleton. FEBS Open Bio 8:1064-1082
Riddle, Daniel L; Slover, James D; Ang, Dennis C et al. (2018) Opioid use prior to knee arthroplasty in patients who catastrophize about their pain: preoperative data from a multisite randomized clinical trial. J Pain Res 11:1549-1557
Jauregui, Catherine; Yoganarasimha, Suyog; Madurantakam, Parthasarathy (2018) Mesenchymal Stem Cells Derived from Healthy and Diseased Human Gingiva Support Osteogenesis on Electrospun Polycaprolactone Scaffolds. Bioengineering (Basel) 5:
Kinser, Patricia Anne; Thacker, Leroy R; Lapato, Dana et al. (2018) Depressive Symptom Prevalence and Predictors in the First Half of Pregnancy. J Womens Health (Larchmt) 27:369-376
Bares, Cristina B; Dick, Danielle M; Kendler, Kenneth S (2018) Nicotine dependence, internalizing symptoms, mood variability and daily tobacco use among young adult smokers. Addict Behav 83:87-94
Vuppalanchi, Raj; Siddiqui, Mohammad S; Van Natta, Mark L et al. (2018) Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease. Hepatology 67:134-144
Darter, Benjamin J; Labrecque, Bethany A; Perera, Robert A (2018) Dynamic stability during split-belt walking and the relationship with step length symmetry. Gait Posture 62:86-91
Cecilione, Jennifer L; Rappaport, Lance M; Hahn, Shannon E et al. (2018) Genetic and Environmental Contributions of Negative Valence Systems to Internalizing Pathways. Twin Res Hum Genet 21:12-23
Docherty, Anna R; Moscati, Arden; Dick, Danielle et al. (2018) Polygenic prediction of the phenome, across ancestry, in emerging adulthood. Psychol Med 48:1814-1823
Khalili, Mandana; Shuhart, Margaret C; Lombardero, Manuel et al. (2018) Relationship Between Metabolic Syndrome, Alanine Aminotransferase Levels, and Liver Disease Severity in a Multiethnic North American Cohort With Chronic Hepatitis B. Diabetes Care 41:1251-1259

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