The Ohio State University created the Center for Clinical and Translational Science (CCTS) to catalyze research teams and facilitate innovation through creation of an environment that fosters translation of knowledge to improve human health. The Center will accomplish four specific aims: 1) Build on the unique and diverse strengths of our institution to create an integrated academic home for innovative, team-oriented clinical and translational science; 2) Enhance and nurture the career development of highly trained investigators, with an emphasis on innovation and transdisciplinary science; 3) Integrate and enhance an administrative infrastructure to optimize the efficient conduct of the highest quality, generalizable clinical and translational science that is relevant to the community setting; 4) Develop, enhance and integrate a portfolio of outstanding shared resources in support of transformative clinical and translational research. The CCTS will continue to focus on integrating the traditional biomedical research process (basic scientific discovery with translation to the bedside to dissemination into the community for improved patient outcomes) with a public health model (surveillance to prevention to response). By incorporating this bi-directional model in the creation of a robust translational science infrastructure, the OSU CCTS will foster both the traditional discovery to best practice paradigm as well as taking advantage of the insight garnered from our foundation of excellence in clinical care to stimulate basic discovery and clinical research inquiry. The vision and specific aims will be achieved through an integrated model of governance and partnership, home, and leadership for clinical and translational research spanning NCH and OSU; focused pilot funding initiatives for new team development within an innovation ecosystem; unique educational and training architecture which integrates acquisition of core competencies in research methodology, interpretation of results, implementation of findings, design thinking, team leadership skills and business acumen with rigorous discipline-specific laboratory (bench, clinical or community) training; and a clinical and translational science infrastructure that is cohesive, innovative and adaptable and more effective than the services that currently exist in order to ensure provision of the full range of disease-agnostic scientific resources needed to traverse the continuum of research from T1-4.

Public Health Relevance

(See Instructions): The Center for Clinical and Translational Science will improve human health by bringing the benefits of science more quickly into patient care.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR001070-05
Application #
9270642
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S1))
Program Officer
Merchant, Carol
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
5
Fiscal Year
2017
Total Cost
$4,011,403
Indirect Cost
$1,090,701
Name
Ohio State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Hu, Zhiwei; Shen, Rulong; Campbell, Amanda et al. (2018) Targeting Tissue Factor for Immunotherapy of Triple-Negative Breast Cancer Using a Second-Generation ICON. Cancer Immunol Res 6:671-684
Laver, T; London, C A; Vail, D M et al. (2018) Prospective evaluation of toceranib phosphate in metastatic canine osteosarcoma. Vet Comp Oncol 16:E23-E29
Hankey, William; Frankel, Wendy L; Groden, Joanna (2018) Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting. Cancer Metastasis Rev 37:159-172
Moore, Sarah A; Zidan, Natalia; Spitzbarth, Ingo et al. (2018) Development of an International Canine Spinal Cord Injury observational registry: a collaborative data-sharing network to optimize translational studies of SCI. Spinal Cord 56:656-665
Pisoni, David B; Broadstock, Arthur; Wucinich, Taylor et al. (2018) Verbal Learning and Memory After Cochlear Implantation in Postlingually Deaf Adults: Some New Findings with the CVLT-II. Ear Hear 39:720-745
Keenan, Brendan T; Kim, Jinyoung; Singh, Bhajan et al. (2018) Recognizable clinical subtypes of obstructive sleep apnea across international sleep centers: a cluster analysis. Sleep 41:
Garcia-MauriƱo, Cristina; Moore-Clingenpeel, Melissa; Wallihan, Rebecca et al. (2018) Discharge Criteria for Bronchiolitis: An Unmet Need. Pediatr Infect Dis J 37:514-519
Barrie, Elizabeth S; Pinsonneault, Julia K; Sadee, Wolfgang et al. (2018) Testing genetic modifiers of behavior and response to atomoxetine in autism spectrum disorder with ADHD. J Dev Phys Disabil 30:355-371
Amici, Stephanie A; Young, Nicholas A; Narvaez-Miranda, Janiret et al. (2018) CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions. Front Immunol 9:1593
Brown, Angela M; Opoku, Faustina Ottie; Stenger, Michael R (2018) Neonatal Contrast Sensitivity and Visual Acuity: Basic Psychophysics. Transl Vis Sci Technol 7:18

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