Abstract

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational (C&T) research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and longstanding partner Meharry, the nation?s oldest historically black academic health science institution. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub with these aims: 1) Leverage VICTR?s strong collaborative energy to enhance team science methodologies that propel transdisciplinary research approaches, and integrate proven community engagement principles to stakeholders for all stages of research; 2) Develop, implement and disseminate informatics and data organization methods to promulgate research efficiency, quality, and preparedness and integrate data collection in the conduct of pragmatic trials; 3) Ensure the translational science workforce is diverse and has the skills, knowledge, and resources necessary to advance translation of discoveries; 4) Measurably improve the efficiency, quality, and representativeness of C&T studies by enhancing and systematically integrating services and programs that support highest quality research initiation and conduct; 5) Measurably improve the efficiency and quality of multi-site clinical trials, in collaboration with the TICs and RICs, by leveraging centralized regulatory and legal agreements, providing rapid feasibility and recruitment methods and practices, and creating and disseminating novel clinical trial designs and methodologies; and 6) Utilize unique strengths leveraging novel resources BioVU and PheWAS to guide drug development and repurposing.

Public Health Relevance

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and Meharry Medical College. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
1UL1TR002243-01
Application #
9414517
Study Section
Special Emphasis Panel (ZTR1-SRC (99))
Program Officer
Urv, Tiina K
Project Start
2017-06-01
Project End
2022-02-28
Budget Start
2017-06-01
Budget End
2018-02-28
Support Year
1
Fiscal Year
2017
Total Cost
$8,020,564
Indirect Cost
$2,716,958

  Institution

Name
Vanderbilt University Medical Center
Department
Type
Independent Hospitals
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232

  Publications

Self, Wesley H; Semler, Matthew W; Wanderer, Jonathan P et al. (2018) Balanced Crystalloids versus Saline in Noncritically Ill Adults. N Engl J Med 378:819-828
Marra, Annachiara; Pandharipande, Pratik P; Girard, Timothy D et al. (2018) Co-Occurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness. Crit Care Med 46:1393-1401
Bruehl, Stephen; Burns, John W; Morgan, Amanda et al. (2018) The association between endogenous opioid function and morphine responsiveness: a moderating role for endocannabinoids. Pain :
Sutherland, Susanna; Brunwasser, Steven M (2018) Sex Differences in Vulnerability to Prenatal Stress: a Review of the Recent Literature. Curr Psychiatry Rep 20:102
Haas, David W; Bradford, Yuki; Verma, Anurag et al. (2018) Brain neurotransmitter transporter/receptor genomics and efavirenz central nervous system adverse events. Pharmacogenet Genomics 28:179-187
Semler, Matthew W; Self, Wesley H; Wanderer, Jonathan P et al. (2018) Balanced Crystalloids versus Saline in Critically Ill Adults. N Engl J Med 378:829-839
Juárez, A Pablo; Weitlauf, Amy S; Nicholson, Amy et al. (2018) Early Identification of ASD Through Telemedicine: Potential Value for Underserved Populations. J Autism Dev Disord 48:2601-2610
Ho, Meng-Hsuan; Lamont, Richard J; Chazin, Walter J et al. (2018) Characterization and development of SAPP as a specific peptidic inhibitor that targets Porphyromonas gingivalis. Mol Oral Microbiol 33:430-439
Bray, Michael J; Wellons, Melissa F; Jones, Sarah H et al. (2018) Transethnic and race-stratified genome-wide association study of fibroid characteristics in African American and European American women. Fertil Steril 110:737-745.e34
Huerta, Luis E; Nelson, George E; Stewart, Thomas G et al. (2018) Factors associated with recurrence and mortality in central line-associated bloodstream infections: a retrospective cohort study. Crit Care 22:266

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