Abstract

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational (C&T) research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and longstanding partner Meharry, the nation?s oldest historically black academic health science institution. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub with these aims: 1) Leverage VICTR?s strong collaborative energy to enhance team science methodologies that propel transdisciplinary research approaches, and integrate proven community engagement principles to stakeholders for all stages of research; 2) Develop, implement and disseminate informatics and data organization methods to promulgate research efficiency, quality, and preparedness and integrate data collection in the conduct of pragmatic trials; 3) Ensure the translational science workforce is diverse and has the skills, knowledge, and resources necessary to advance translation of discoveries; 4) Measurably improve the efficiency, quality, and representativeness of C&T studies by enhancing and systematically integrating services and programs that support highest quality research initiation and conduct; 5) Measurably improve the efficiency and quality of multi-site clinical trials, in collaboration with the TICs and RICs, by leveraging centralized regulatory and legal agreements, providing rapid feasibility and recruitment methods and practices, and creating and disseminating novel clinical trial designs and methodologies; and 6) Utilize unique strengths leveraging novel resources BioVU and PheWAS to guide drug development and repurposing.

Public Health Relevance

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and Meharry Medical College. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
1UL1TR002243-01
Application #
9414517
Study Section
Special Emphasis Panel (ZTR1-SRC (99))
Program Officer
Urv, Tiina K
Project Start
2017-06-01
Project End
2022-02-28
Budget Start
2017-06-01
Budget End
2018-02-28
Support Year
1
Fiscal Year
2017
Total Cost
$8,020,564
Indirect Cost
$2,716,958

  Institution

Name
Vanderbilt University Medical Center
Department
Type
Independent Hospitals
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232

  Publications

Fish, Alexandra E; Crawford, Dana C; Capra, John A et al. (2018) Local ancestry transitions modify snp-trait associations. Pac Symp Biocomput 23:424-435
Jerome, Rebecca N; Pulley, Jill M; Roden, Dan M et al. (2018) Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors. Drug Saf 41:303-311
Barnado, April; Carroll, Robert J; Casey, Carolyn et al. (2018) Phenome-Wide Association Studies Uncover a Novel Association of Increased Atrial Fibrillation in Male Patients With Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken) 70:1630-1636
Cohn, Joshua A; Shah, Avantika S; Goggins, Kathryn M et al. (2018) Health literacy, cognition, and urinary incontinence among geriatric inpatients discharged to skilled nursing facilities. Neurourol Urodyn 37:854-860
Abi Zeid Daou, Margarita; Boyd, Brian D; Donahue, Manus J et al. (2018) Anterior-posterior gradient differences in lobar and cingulate cortex cerebral blood flow in late-life depression. J Psychiatr Res 97:1-7
Forbes, Rachel C; Feurer, Irene D; LaNeve, David et al. (2018) Increasing kidney donor profile index sequence does not adversely affect medium-term health-related quality of life after kidney transplantation. Clin Transplant 32:e13212
Sterling, Madeline R; Safford, Monika M; Goggins, Kathryn et al. (2018) Numeracy, Health Literacy, Cognition, and 30-Day Readmissions among Patients with Heart Failure. J Hosp Med 13:145-151
Choksi, Yash A; Reddy, Vishruth K; Singh, Kshipra et al. (2018) BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol 11:1363-1374
Hellwege, Jacklyn N; Russell, Shirley B; Williams, Scott M et al. (2018) Gene-based evaluation of low-frequency variation and genetically-predicted gene expression impacting risk of keloid formation. Ann Hum Genet 82:206-215
Yiadom, Maame Yaa A B; Domenico, Henry; Byrne, Daniel et al. (2018) Randomised controlled pragmatic clinical trial evaluating the effectiveness of a discharge follow-up phone call on 30-day hospital readmissions: balancing pragmatic and explanatory design considerations. BMJ Open 8:e019600

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