Abstract

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational (C&T) research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and longstanding partner Meharry, the nation?s oldest historically black academic health science institution. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub with these aims: 1) Leverage VICTR?s strong collaborative energy to enhance team science methodologies that propel transdisciplinary research approaches, and integrate proven community engagement principles to stakeholders for all stages of research; 2) Develop, implement and disseminate informatics and data organization methods to promulgate research efficiency, quality, and preparedness and integrate data collection in the conduct of pragmatic trials; 3) Ensure the translational science workforce is diverse and has the skills, knowledge, and resources necessary to advance translation of discoveries; 4) Measurably improve the efficiency, quality, and representativeness of C&T studies by enhancing and systematically integrating services and programs that support highest quality research initiation and conduct; 5) Measurably improve the efficiency and quality of multi-site clinical trials, in collaboration with the TICs and RICs, by leveraging centralized regulatory and legal agreements, providing rapid feasibility and recruitment methods and practices, and creating and disseminating novel clinical trial designs and methodologies; and 6) Utilize unique strengths leveraging novel resources BioVU and PheWAS to guide drug development and repurposing.

Public Health Relevance

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and Meharry Medical College. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
1UL1TR002243-01
Application #
9414517
Study Section
Special Emphasis Panel (ZTR1-SRC (99))
Program Officer
Urv, Tiina K
Project Start
2017-06-01
Project End
2022-02-28
Budget Start
2017-06-01
Budget End
2018-02-28
Support Year
1
Fiscal Year
2017
Total Cost
$8,020,564
Indirect Cost
$2,716,958

  Institution

Name
Vanderbilt University Medical Center
Department
Type
Independent Hospitals
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232

  Publications

Brunwasser, Steven M; Gebretsadik, Tebeb; Gold, Diane R et al. (2018) A new model of wheezing severity in young children using the validated ISAAC wheezing module: A latent variable approach with validation in independent cohorts. PLoS One 13:e0194739
Sevin, Carla M; Bloom, Sarah L; Jackson, James C et al. (2018) Comprehensive care of ICU survivors: Development and implementation of an ICU recovery center. J Crit Care 46:141-148
Nath, Vishwesh; Schilling, Kurt G; Hainline, Allison E et al. (2018) SHARD: Spherical Harmonic-based Robust Outlier Detection for HARDI Methods. Proc SPIE Int Soc Opt Eng 10574:
Bradham, William; Ormseth, Michelle J; Elumogo, Comfort et al. (2018) Absence of Fibrosis and Inflammation by Cardiac Magnetic Resonance Imaging in Rheumatoid Arthritis Patients with Low to Moderate Disease Activity. J Rheumatol 45:1078-1084
Huo, Yuankai; Xu, Zhoubing; Bao, Shunxing et al. (2018) Splenomegaly Segmentation using Global Convolutional Kernels and Conditional Generative Adversarial Networks. Proc SPIE Int Soc Opt Eng 10574:
Scoville, Elizabeth A; Allaman, Margaret M; Brown, Caroline T et al. (2018) Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics 14:
Bao, Shunxing; Huo, Yuankai; Parvathaneni, Prasanna et al. (2018) A Data Colocation Grid Framework for Big Data Medical Image Processing: Backend Design. Proc SPIE Int Soc Opt Eng 10597:
Silva, Flavio M; Brismée, Jean-Michel; Sizer, Phillip S et al. (2018) Musicians injuries: Upper quarter motor control deficits in musicians with prolonged symptoms - A case-control study. Musculoskelet Sci Pract 36:54-60
Barnado, April; Carroll, Robert J; Casey, Carolyn et al. (2018) Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus. Arthritis Res Ther 20:69
Bobo, Meg F; Bao, Shunxing; Huo, Yuankai et al. (2018) Fully Convolutional Neural Networks Improve Abdominal Organ Segmentation. Proc SPIE Int Soc Opt Eng 10574:

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