Abstract

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational (C&T) research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and longstanding partner Meharry, the nation?s oldest historically black academic health science institution. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub with these aims: 1) Leverage VICTR?s strong collaborative energy to enhance team science methodologies that propel transdisciplinary research approaches, and integrate proven community engagement principles to stakeholders for all stages of research; 2) Develop, implement and disseminate informatics and data organization methods to promulgate research efficiency, quality, and preparedness and integrate data collection in the conduct of pragmatic trials; 3) Ensure the translational science workforce is diverse and has the skills, knowledge, and resources necessary to advance translation of discoveries; 4) Measurably improve the efficiency, quality, and representativeness of C&T studies by enhancing and systematically integrating services and programs that support highest quality research initiation and conduct; 5) Measurably improve the efficiency and quality of multi-site clinical trials, in collaboration with the TICs and RICs, by leveraging centralized regulatory and legal agreements, providing rapid feasibility and recruitment methods and practices, and creating and disseminating novel clinical trial designs and methodologies; and 6) Utilize unique strengths leveraging novel resources BioVU and PheWAS to guide drug development and repurposing.

Public Health Relevance

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and Meharry Medical College. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR002243-02S1
Application #
9654067
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Gopal-Srivastava, Rashmi
Project Start
2017-06-01
Project End
2022-02-28
Budget Start
2018-03-26
Budget End
2019-02-28
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232

  Publications

Kummerow Broman, Kristy; Ward, Michael J; Poulose, Benjamin K et al. (2018) Surgical Transfer Decision Making: How Regional Resources are Allocated in a Regional Transfer Network. Jt Comm J Qual Patient Saf 44:33-42
Burke, Meghan M; Waitz-Kudla, Sydney N; Rabideau, Carol et al. (2018) Pulling back the curtain: Issues in conducting an intervention study with transition-aged youth with autism spectrum disorder and their families. Autism :1362361317753016
O'Connor, Amy M; Smith, Andrew H; Crum, Kim et al. (2018) Analysis of clinical and candidate genetic risk factors for postoperative atrial tachycardia after congenital heart surgery in infants. Am Heart J 202:1-4
Dahir, Kathryn M; Tilden, Daniel R; Warner, Jeremy L et al. (2018) Rare Variants in the Gene ALPL That Cause Hypophosphatasia Are Strongly Associated With Ovarian and Uterine Disorders. J Clin Endocrinol Metab 103:2234-2243
Strickland, Stephen A; Shaver, Aaron C; Byrne, Michael et al. (2018) Genotypic and clinical heterogeneity within NCCN favorable-risk acute myeloid leukemia. Leuk Res 65:67-73
Rosas-Salazar, Christian; Shilts, Meghan H; Tovchigrechko, Andrey et al. (2018) Nasopharyngeal Lactobacillus is associated with a reduced risk of childhood wheezing illnesses following acute respiratory syncytial virus infection in infancy. J Allergy Clin Immunol 142:1447-1456.e9
Shibao, Cyndya A; Celedonio, Jorge E; Tamboli, Robyn et al. (2018) CD36 Modulates Fasting and Preabsorptive Hormone and Bile Acid Levels. J Clin Endocrinol Metab 103:1856-1866
Bejan, Cosmin A; Angiolillo, John; Conway, Douglas et al. (2018) Mining 100 million notes to find homelessness and adverse childhood experiences: 2 case studies of rare and severe social determinants of health in electronic health records. J Am Med Inform Assoc 25:61-71
Saito-Diaz, Kenyi; Benchabane, Hassina; Tiwari, Ajit et al. (2018) APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. Dev Cell 44:566-581.e8
Bagnato, Francesca; Hametner, Simon; Franco, Giulia et al. (2018) Selective Inversion Recovery Quantitative Magnetization Transfer Brain MRI at 7T: Clinical and Postmortem Validation in Multiple Sclerosis. J Neuroimaging 28:380-388

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