Abstract

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational (C&T) research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and longstanding partner Meharry, the nation?s oldest historically black academic health science institution. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub with these aims: 1) Leverage VICTR?s strong collaborative energy to enhance team science methodologies that propel transdisciplinary research approaches, and integrate proven community engagement principles to stakeholders for all stages of research; 2) Develop, implement and disseminate informatics and data organization methods to promulgate research efficiency, quality, and preparedness and integrate data collection in the conduct of pragmatic trials; 3) Ensure the translational science workforce is diverse and has the skills, knowledge, and resources necessary to advance translation of discoveries; 4) Measurably improve the efficiency, quality, and representativeness of C&T studies by enhancing and systematically integrating services and programs that support highest quality research initiation and conduct; 5) Measurably improve the efficiency and quality of multi-site clinical trials, in collaboration with the TICs and RICs, by leveraging centralized regulatory and legal agreements, providing rapid feasibility and recruitment methods and practices, and creating and disseminating novel clinical trial designs and methodologies; and 6) Utilize unique strengths leveraging novel resources BioVU and PheWAS to guide drug development and repurposing.

Public Health Relevance

The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational research infrastructure that has raised the quality and scientific rigor of the research conducted at Vanderbilt and Meharry Medical College. VICTR will contribute to the mission of the CTSA program while leveraging unique resources and expertise within VICTR?s Hub.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR002243-03
Application #
9666956
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Gopal-Srivastava, Rashmi
Project Start
2017-06-01
Project End
2022-02-28
Budget Start
2019-03-01
Budget End
2020-02-29
Support Year
3
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232

  Publications

Turi, Kedir N; Shankar, Jyoti; Anderson, Larry J et al. (2018) Infant Viral Respiratory Infection Nasal Immune-Response Patterns and Their Association with Subsequent Childhood Recurrent Wheeze. Am J Respir Crit Care Med 198:1064-1073
Jerome, Rebecca N; Pulley, Jill M; Roden, Dan M et al. (2018) Reply to Ward and Colleagues' Comment on ""Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors"". Drug Saf 41:1101
Martinez, William; Threatt, Anthony L; Rosenbloom, S Trent et al. (2018) A Patient-Facing Diabetes Dashboard Embedded in a Patient Web Portal: Design Sprint and Usability Testing. JMIR Hum Factors 5:e26
Canedo, Juan R; Miller, Stephania T; Schlundt, David et al. (2018) Racial/Ethnic Disparities in Diabetes Quality of Care: the Role of Healthcare Access and Socioeconomic Status. J Racial Ethn Health Disparities 5:7-14
Hiremath, Girish; Kodroff, Ellyn; Strobel, Mary J et al. (2018) Individuals affected by eosinophilic gastrointestinal disorders have complex unmet needs and frequently experience unique barriers to care. Clin Res Hepatol Gastroenterol 42:483-493
Sabato, Leah A; Johnson, Daniel C; Haglund, Nicholas et al. (2018) Pharmacokinetics of Sildenafil in Patients with a Left Ventricular Assist Device: A Word of Caution. ASAIO J :
Mefferd, Antje S; Lai, Abish; Bagnato, Francesca (2018) A first investigation of tongue, lip, and jaw movements in persons with dysarthria due to multiple sclerosis. Mult Scler Relat Disord 27:188-194
Ramer, Sarah J; McCall, Natalie N; Robinson-Cohen, Cassianne et al. (2018) Health Outcome Priorities of Older Adults with Advanced CKD and Concordance with Their Nephrology Providers' Perceptions. J Am Soc Nephrol 29:2870-2878
Marra, Annachiara; Pandharipande, Pratik P; Girard, Timothy D et al. (2018) Co-Occurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness. Crit Care Med 46:1393-1401
Bruehl, Stephen; Burns, John W; Morgan, Amanda et al. (2018) The association between endogenous opioid function and morphine responsiveness: a moderating role for endocannabinoids. Pain :

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