The Shanghai Women's Health Study (SWHS, R37 CA070867) is a population-based cohort study of approximately 75,000 Chinese women who were recruited between 1997 and 2000 and have been followed via multiple in-person surveys and record linkages with population-based registries. Over the years, data and biological samples collected in the SWMS have been used to evaluate many important etiologic hypotheses and support multiple studies, including about 40 research consortia. To sustain and expand SWHS resources and success, we are applying for infrastructure funding.
Specific aims : 1) Continue cohort follow-up for cancer incidence and cause-specific mortality and conduct additional in-person interviews to obtain information regarding exposures and selected disease outcomes;2) Maintain SWHS data bank and biorepository to support research and facilitate data sharing with the scientific community;3) Collect and store stool samples from approximately 40,000 living cohort members for future research of fecal microbiota and other biomarkers;4) Establish resources for clinical and pharmaco-epidemiologic research through linkage with population-based electronic medical databases;5) Continue to collect tumor tissue samples among cohort members diagnosed with cancer to study tumor markers. The SWHS, with its large sample size, wealth of resources, and unique exposure patterns and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in other existing cohorts. Results from the SWHS will have significant impact on reducing the incidence and mortality of cancer and other noncommunicable diseases, the major causes of death in most countries.

Public Health Relevance

The Shanghai Women's Health Study is a population-based cohort study of approximately 75,000 women who were recruited between 1997 and 2000. This cohort study will provide exceptional opportunities to investigate many highly significant issues related to the etiology, genetics, and prevention of cancer and noncommunicable diseases.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O2))
Program Officer
Mahabir, Somdat
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Zhu, Jingjing; Xiang, Yong-Bing; Cai, Hui et al. (2018) Associations of obesity and weight change with physical and mental impairments in elderly Chinese people. Maturitas 108:77-83
Yang, Yang; Gao, Jing; Tan, Yu-Ting et al. (2018) Individual and combined effects of hepatitis B surface antigen level and viral load on liver cancer risk. J Gastroenterol Hepatol 33:1131-1137
Ma, Xiao; Tan, Yu-Ting; Yang, Yang et al. (2018) Pre-diagnostic urinary 15-F2t -isoprostane level and liver cancer risk: Results from the Shanghai Women's and Men's Health Studies. Int J Cancer 143:1896-1903
Theofylaktopoulou, Despoina; Midttun, Øivind; Ueland, Per M et al. (2018) Impaired functional vitamin B6 status is associated with increased risk of lung cancer. Int J Cancer 142:2425-2434
Jung, Seungyoun; Allen, Naomi; Arslan, Alan A et al. (2018) Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts. Int J Cancer 142:262-270
Zhu, Jingjing; Xiang, Yong-Bing; Cai, Hui et al. (2018) A Prospective Investigation of Dietary Intake and Functional Impairments Among the Elderly. Am J Epidemiol 187:2372-2386
Yu, Danxia; Zheng, Wei; Cai, Hui et al. (2018) Long-term Diet Quality and Risk of Type 2 Diabetes Among Urban Chinese Adults. Diabetes Care 41:723-730
Shu, Xiang; Xiang, Yong-Bing; Rothman, Nathaniel et al. (2018) Prospective study of blood metabolites associated with colorectal cancer risk. Int J Cancer 143:527-534
Varga, Matthew G; Wang, Tianyi; Cai, Hui et al. (2018) Helicobacter pylori Blood Biomarkers and Gastric Cancer Survival in China. Cancer Epidemiol Biomarkers Prev 27:342-344
Muller, D C; Hodge, A M; Fanidi, A et al. (2018) No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3). Ann Oncol 29:1468-1475

Showing the most recent 10 out of 152 publications