The Shanghai Women's Health Study (SWHS, R37 CA070867) is a population-based cohort study of approximately 75,000 Chinese women who were recruited between 1997 and 2000 and have been followed via multiple in-person surveys and record linkages with population-based registries. Over the years, data and biological samples collected in the SWMS have been used to evaluate many important etiologic hypotheses and support multiple studies, including about 40 research consortia. To sustain and expand SWHS resources and success, we are applying for infrastructure funding.
Specific aims : 1) Continue cohort follow-up for cancer incidence and cause-specific mortality and conduct additional in-person interviews to obtain information regarding exposures and selected disease outcomes; 2) Maintain SWHS data bank and biorepository to support research and facilitate data sharing with the scientific community; 3) Collect and store stool samples from approximately 40,000 living cohort members for future research of fecal microbiota and other biomarkers; 4) Establish resources for clinical and pharmaco-epidemiologic research through linkage with population-based electronic medical databases; 5) Continue to collect tumor tissue samples among cohort members diagnosed with cancer to study tumor markers. The SWHS, with its large sample size, wealth of resources, and unique exposure patterns and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in other existing cohorts. Results from the SWHS will have significant impact on reducing the incidence and mortality of cancer and other noncommunicable diseases, the major causes of death in most countries.

Public Health Relevance

The Shanghai Women's Health Study is a population-based cohort study of approximately 75,000 women who were recruited between 1997 and 2000. This cohort study will provide exceptional opportunities to investigate many highly significant issues related to the etiology, genetics, and prevention of cancer and noncommunicable diseases.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project with Complex Structure Cooperative Agreement (UM1)
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Special Emphasis Panel (ZCA1)
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Mahabir, Somdat
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Vanderbilt University Medical Center
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Liu, Qiaolan; Cai, Hui; Yang, Lawrence H et al. (2018) Depressive symptoms and their association with social determinants and chronic diseases in middle-aged and elderly Chinese people. Sci Rep 8:3841
Shu, Xiang; Zheng, Wei; Yu, Danxia et al. (2018) Prospective metabolomics study identifies potential novel blood metabolites associated with pancreatic cancer risk. Int J Cancer 143:2161-2167
Earp, Madalene; Tyrer, Jonathan P; Winham, Stacey J et al. (2018) Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. PLoS One 13:e0197561
Varga, Matthew G; Cai, Hui; Waterboer, Tim et al. (2018) Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia. Dig Dis Sci 63:2765-2772
Wu, Jie; Cai, Hui; Xiang, Yong-Bing et al. (2018) Intra-individual variation of miRNA expression levels in human plasma samples. Biomarkers 23:339-346
Wu, Lang; Zheng, Wei; Xiang, Yong-Bing et al. (2018) Physical Activity and Pancreatic Cancer Risk among Urban Chinese: Results from Two Prospective Cohort Studies. Cancer Epidemiol Biomarkers Prev 27:479-487
Luu, Hung N; Cai, Hui; Murff, Harvey J et al. (2018) A prospective study of dietary polyunsaturated fatty acids intake and lung cancer risk. Int J Cancer 143:2225-2237
Zhu, Jingjing; Xiang, Yong-Bing; Cai, Hui et al. (2018) Associations of obesity and weight change with physical and mental impairments in elderly Chinese people. Maturitas 108:77-83
Yang, Yang; Gao, Jing; Tan, Yu-Ting et al. (2018) Individual and combined effects of hepatitis B surface antigen level and viral load on liver cancer risk. J Gastroenterol Hepatol 33:1131-1137
Ma, Xiao; Tan, Yu-Ting; Yang, Yang et al. (2018) Pre-diagnostic urinary 15-F2t -isoprostane level and liver cancer risk: Results from the Shanghai Women's and Men's Health Studies. Int J Cancer 143:1896-1903

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