The Shanghai Women's Health Study (SWHS, R37 CA070867) is a population-based cohort study of approximately 75,000 Chinese women who were recruited between 1997 and 2000 and have been followed via multiple in-person surveys and record linkages with population-based registries. Over the years, data and biological samples collected in the SWMS have been used to evaluate many important etiologic hypotheses and support multiple studies, including about 40 research consortia. To sustain and expand SWHS resources and success, we are applying for infrastructure funding.
Specific aims : 1) Continue cohort follow-up for cancer incidence and cause-specific mortality and conduct additional in-person interviews to obtain information regarding exposures and selected disease outcomes; 2) Maintain SWHS data bank and biorepository to support research and facilitate data sharing with the scientific community; 3) Collect and store stool samples from approximately 40,000 living cohort members for future research of fecal microbiota and other biomarkers; 4) Establish resources for clinical and pharmaco-epidemiologic research through linkage with population-based electronic medical databases; 5) Continue to collect tumor tissue samples among cohort members diagnosed with cancer to study tumor markers. The SWHS, with its large sample size, wealth of resources, and unique exposure patterns and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in other existing cohorts. Results from the SWHS will have significant impact on reducing the incidence and mortality of cancer and other noncommunicable diseases, the major causes of death in most countries.
The Shanghai Women's Health Study is a population-based cohort study of approximately 75,000 women who were recruited between 1997 and 2000. This cohort study will provide exceptional opportunities to investigate many highly significant issues related to the etiology, genetics, and prevention of cancer and noncommunicable diseases.
|Varga, Matthew G; Wang, Tianyi; Cai, Hui et al. (2018) Helicobacter pylori Blood Biomarkers and Gastric Cancer Survival in China. Cancer Epidemiol Biomarkers Prev 27:342-344|
|Muller, D C; Hodge, A M; Fanidi, A et al. (2018) No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3). Ann Oncol 29:1468-1475|
|Liu, Qiaolan; Cai, Hui; Yang, Lawrence H et al. (2018) Depressive symptoms and their association with social determinants and chronic diseases in middle-aged and elderly Chinese people. Sci Rep 8:3841|
|Shu, Xiang; Zheng, Wei; Yu, Danxia et al. (2018) Prospective metabolomics study identifies potential novel blood metabolites associated with pancreatic cancer risk. Int J Cancer 143:2161-2167|
|Earp, Madalene; Tyrer, Jonathan P; Winham, Stacey J et al. (2018) Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. PLoS One 13:e0197561|
|Varga, Matthew G; Cai, Hui; Waterboer, Tim et al. (2018) Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia. Dig Dis Sci 63:2765-2772|
|Wu, Jie; Cai, Hui; Xiang, Yong-Bing et al. (2018) Intra-individual variation of miRNA expression levels in human plasma samples. Biomarkers 23:339-346|
|Wu, Lang; Zheng, Wei; Xiang, Yong-Bing et al. (2018) Physical Activity and Pancreatic Cancer Risk among Urban Chinese: Results from Two Prospective Cohort Studies. Cancer Epidemiol Biomarkers Prev 27:479-487|
|Luu, Hung N; Cai, Hui; Murff, Harvey J et al. (2018) A prospective study of dietary polyunsaturated fatty acids intake and lung cancer risk. Int J Cancer 143:2225-2237|
|Zhu, Jingjing; Xiang, Yong-Bing; Cai, Hui et al. (2018) Associations of obesity and weight change with physical and mental impairments in elderly Chinese people. Maturitas 108:77-83|
Showing the most recent 10 out of 152 publications