Abstract

To identify alcoholism risk genes, we are collecting and testing for linkage and pattern of genetic transmission families from three different American Indian populations which are relatively homogeneous and in which alcoholism is highly prevalent. This study also addresses the genetic epidemiology and psychiatry comorbidity of alcoholism in American Indians using structured psychiatric diagnostic interviews of subjects in large families. Data sets of Cheyenne Indian and Pima Indian subjects from large families have been collected. A large panel of random polymorphic probes is being typed in Pima Indian and Cheyenne Indian alcoholics and controls and genetic linkage and transmission analyses are in progress for these groups. An analysis of psychiatric comorbidity in Pima Indian alcoholics and nonalcoholics has been completed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000281-07
Application #
2565459
Study Section
Special Emphasis Panel (LNG)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Landefeld, Clare C; Hodgkinson, Colin A; Spagnolo, Primavera A et al. (2018) Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors. Transl Psychiatry 8:72
Hong, L E; Yang, X; Wonodi, I et al. (2011) A CHRNA5 allele related to nicotine addiction and schizophrenia. Genes Brain Behav 10:530-5
O'Malley, Stephanie S; Robin, Robert W; Levenson, Aryeh L et al. (2008) Naltrexone alone and with sertraline for the treatment of alcohol dependence in Alaska natives and non-natives residing in rural settings: a randomized controlled trial. Alcohol Clin Exp Res 32:1271-83
Ducci, F; Enoch, M-A; Hodgkinson, C et al. (2008) Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Mol Psychiatry 13:334-47
Robin, Robert W; Gottesman, Irving I; Albaugh, Bernard et al. (2007) Schizophrenia and psychotic symptoms in families of two American Indian tribes. BMC Psychiatry 7:30
Barnett, Jennifer H; Heron, Jon; Ring, Susan M et al. (2007) Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children. Am J Psychiatry 164:142-9
Oquendo, Maria A; Hastings, Ramin S; Huang, Yung-Yu et al. (2007) Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Arch Gen Psychiatry 64:201-8
Clarimon, Jordi; Gray, Rebecca R; Williams, Lindsey N et al. (2007) Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations. Alcohol Clin Exp Res 31:546-54
Minzenberg, Michael J; Xu, Ke; Mitropoulou, Vivian et al. (2006) Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups. Psychiatr Genet 16:117-24
Enoch, Mary-Anne; Schwartz, Lori; Albaugh, Bernard et al. (2006) Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. Am J Med Genet B Neuropsychiatr Genet 141:599-607

Showing the most recent 10 out of 34 publications