An analytical method using high performance liquid chromatography (HPLC) with ultraviolet detection was developed for the measurement of bromocriptine, a dopaminergic agonist, in plasma and brain of rats. HPLC assays for chlorambucil and lipophilic derivatives were developed. Gas chromatographic/mass spectrometric assays for arecoline and scopolamine in rat plasma and brain and in human plasma were developed. The age-dependent pharmacokinetics of metachlorochlorophenylpiperazine, a serotonin autoreceptor agonist, were determined in rats.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000128-10
Application #
3808866
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1990
Total Cost
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code