An analytical method using high performance liquid chromatography (HPLC) with fluorescence detection was developed for the measurement of physostigmine, a cholinesterase inhibitor, in plasma of humans receiving the drug as a treatment for Alzheimer's disease. A gas chromatographic/mass spectrometric assay for the measurement of nicotine in rat plasma and brain and in human plasma was developed.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000128-12
Application #
3789761
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1992
Total Cost
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code