Abstract

The advance of genomics has led to the definition of thousands of human genes as well as the identification of a significant proportion of genes in other non-human organisms. We are utilizing these advanced genomic resources coupled with modern engineering and informatics capabilities to establish a cDNA microarray center laboratory. Microarrays allow for the simultaneous monitoring of gene expression changes relative to control in thousands of genes. It is the goal of this lab to aid intramural and extramural investigators in understanding how environmental agents may affect gene expression, and thus increase our knowledge of the mechanism of action of such agents. In the past year significant progress has been made to assemble all of the necessary components for this work and investigation of the gene expression signatures for estrogen and oxidant stressors in defined human tissue culture models has begun. - Microarray, estrogen, carcinogen, non-genotoxic, gene expression, arsenic

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES023026-01
Application #
6227935
Study Section
Special Emphasis Panel (LMC)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
National Institute of Environmental Health Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Ferrucio, Bianca; Tiago, Manoela; Fannin, Richard D et al. (2017) Molecular effects of 1-naphthyl-methylcarbamate and solar radiation exposures on human melanocytes. Toxicol In Vitro 38:67-76
Cui, Yuxia; Huang, Qihong; Auman, James Todd et al. (2011) Genomic-derived markers for early detection of calcineurin inhibitor immunosuppressant-mediated nephrotoxicity. Toxicol Sci 124:23-34
Kienhuis, Anne S; van de Poll, Marcel C G; Wortelboer, Heleen et al. (2009) Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans. Toxicol Sci 107:544-52
Chou, Jeff W; Zhou, Tong; Kaufmann, William K et al. (2007) Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes. BMC Bioinformatics 8:427
Auman, J Todd; Chou, Jeff; Gerrish, Kevin et al. (2007) Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue. Environ Health Perspect 115:572-8
Auman, J Todd; Boorman, Gary A; Wilson, Ralph E et al. (2007) Heat map visualization of high-density clinical chemistry data. Physiol Genomics 31:352-6
Kim, Yongbaek; Ton, Thai-Vu; DeAngelo, Anthony B et al. (2006) Major carcinogenic pathways identified by gene expression analysis of peritoneal mesotheliomas following chemical treatment in F344 rats. Toxicol Appl Pharmacol 214:144-51
Paules, R S (2006) Toxicogenomics and environmental diseases: the search for biomarkers predictive of adverse effects. Med Lav 97:322-3
Kang, Hong Soon; Beak, Ju Youn; Kim, Yong-Sik et al. (2006) NABP1, a novel RORgamma-regulated gene encoding a single-stranded nucleic-acid-binding protein. Biochem J 397:89-99
Hewitt, Sylvia C; Collins, Jennifer; Grissom, Sherry et al. (2006) Estren behaves as a weak estrogen rather than a nongenomic selective activator in the mouse uterus. Endocrinology 147:2203-14

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