of Work: This project focuses on menstrual cycle characteristics, menarche, menopause, and pregnancy history as risk factors for diseases hormonally-mediated diseases (e.g. osteoporosis, coronary heart disease) and diseases that only effect women (e.g., ovarian cancer). 1) We are using a unique data source: prospectively collected menstrual cycle data from 997 college-aged women who participated in a menstrual diary study in the 1930's. Follow-up of the health status of members of this cohort was conducted in 1989-91 using a mailed questionnaire and death certificate searches. We have analyzed the association between menstrual cycle characteristics and peri- and post- menopausal fractures: Wrist fracture (n=62) risk increased with increasing age at menarche (odds ratio, OR, 3.3, 95%CI (1.7-6.2) for menarche age greater than or equal to 14 compared to 12 -13 years old) and increasing mean cycle length at age 28 - 32 (OR 2.2 (95% CI (1.0-4.9) for > 30.5 days compared to 26.6 - 30.5 days), and increasing bleeding duration (OR 1.7 for > 6.0 days compared to 4.7 - 6.0 days). Similar results were seen in analyses of the combined wrist, hip, or vertebral fracture group (n=92). We are currently analyzing the menstrual, reproductive, and menopausal risk factors in relation to risk of coronary heart disease and ovarall mortality in the cohort. 2) We are examining the association between risk of ovarian cancer and age at first birth, age at last birth, and menopausal status using data from 4 previously conducted case-control studies. These studies include a wide age range of ovarian cancer cases (ages 18-78) and allow us to examine the potential modifying or confounding effects of family history, oral contraceptive use, tubal ligation, and infertility.
| Farr, Sherry L; Cai, Jianwen; Savitz, David A et al. (2006) Pesticide exposure and timing of menopause: the Agricultural Health Study. Am J Epidemiol 163:731-42 |
| Cooper, Glinda S; Klebanoff, Mark A; Promislow, Joanne et al. (2005) Polychlorinated biphenyls and menstrual cycle characteristics. Epidemiology 16:191-200 |
| Cooper, Glinda S; Longnecker, Matthew P; Peters, Ruth K (2004) Ovarian cancer risk and use of phenolphthalein-containing laxatives. Pharmacoepidemiol Drug Saf 13:35-9 |
| Farr, S L; Cooper, G S; Cai, J et al. (2004) Pesticide use and menstrual cycle characteristics among premenopausal women in the Agricultural Health Study. Am J Epidemiol 160:1194-204 |
| Brett, Kate M; Cooper, Glinda S (2003) Associations with menopause and menopausal transition in a nationally representative US sample. Maturitas 45:89-97 |
| Cooper, Glinda S; Savitz, David A; Millikan, Robert et al. (2002) Organochlorine exposure and age at natural menopause. Epidemiology 13:729-33 |
| Cooper, Glinda S (2002) Hormone replacement following early menopause. JAMA 288:2824-5; author reply 2825 |
| Cooper, G S; Ephross, S A; Sandler, D P (2000) Menstrual patterns and risk of adult-onset diabetes mellitus. J Clin Epidemiol 53:1170-3 |
| Cooper, G S; Longnecker, M P; Sandler, D P et al. (2000) Risk of ovarian cancer in relation to use of phenolphthalein-containing laxatives. Br J Cancer 83:404-6 |
| Chie, W C; Hsieh, C; Newcomb, P A et al. (2000) Age at any full-term pregnancy and breast cancer risk. Am J Epidemiol 151:715-22 |
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