Accomplishments: We examined ovarian cancer risk in relation to use of phenolphthalein-containing laxatives in 410 epithelial ovarian cancer cases and 713 controls. Compared to women who never used a laxative, ever use of a phenolphthalein-containing laxative was not associated (OR 1.1, 95% CI 0.9 !1.4) with an increased risk of ovarian cancer. Risk was slightly higher with more frequent use (OR 1.2 for 75 or more days of use). When women who used non-phenolphthalein containing laxatives was used as the reference group, the associations were slightly larger: OR 1.4 for any use of phenolphthalein-containing laxatives and OR 1.5 for 75 or more days of use.
Farr, Sherry L; Cai, Jianwen; Savitz, David A et al. (2006) Pesticide exposure and timing of menopause: the Agricultural Health Study. Am J Epidemiol 163:731-42 |
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Cooper, Glinda S; Longnecker, Matthew P; Peters, Ruth K (2004) Ovarian cancer risk and use of phenolphthalein-containing laxatives. Pharmacoepidemiol Drug Saf 13:35-9 |
Farr, S L; Cooper, G S; Cai, J et al. (2004) Pesticide use and menstrual cycle characteristics among premenopausal women in the Agricultural Health Study. Am J Epidemiol 160:1194-204 |
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Cooper, Glinda S (2002) Hormone replacement following early menopause. JAMA 288:2824-5; author reply 2825 |
Cooper, G S; Ephross, S A; Sandler, D P (2000) Menstrual patterns and risk of adult-onset diabetes mellitus. J Clin Epidemiol 53:1170-3 |
Cooper, G S; Longnecker, M P; Sandler, D P et al. (2000) Risk of ovarian cancer in relation to use of phenolphthalein-containing laxatives. Br J Cancer 83:404-6 |
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