This study is a linkage analysis of families with human prostate cancer. A paper published in Science in 1996 by this group indicates the possibility of linkage of a locus for prostate cancer to a region of chromosome 1. This has been followed up this year by intensive linkage analyses of additional families to markers in this region and in other regions that showed some mild evidence of linkage in the initial genome scan. Families have been obtained and genotyped from several regions of the United States, Finland and Sweden. Efforts are also underway to develop additional family resources for this project. A second locus on the X chromosome has been mapped by linkage analysis in this fiscal year with results published in Nature Genetics, 20:175-179 (1998). These investigators have also joined a national Prostate Cancer Linkage Consortium to try to localize prostate cancerloci more rapidly. This project to identify and clone genes for prostate cancer is ongoing.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Intramural Research (Z01)
Project #
1Z01HG000107-02
Application #
6109033
Study Section
Special Emphasis Panel (IDRB)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
National Human Genome Research Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Gillanders, Elizabeth M; Xu, Jianfeng; Chang, Bao-li et al. (2004) Combined genome-wide scan for prostate cancer susceptibility genes. J Natl Cancer Inst 96:1240-7
Carpten, J; Nupponen, N; Isaacs, S et al. (2002) Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet 30:181-4
Ho, Gloria Y F; Knapp, Michael; Freije, Diha et al. (2002) Transmission/disequilibrium tests of androgen receptor and glutathione S-transferase pi variants in prostate cancer families. Int J Cancer 98:938-42
Rokman, Annika; Ikonen, Tarja; Seppala, Eija H et al. (2002) Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. Am J Hum Genet 70:1299-304
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Powell, I J; Carpten, J; Dunston, G et al. (2001) African-American heredity prostate cancer study: a model for genetic research. J Natl Med Assoc 93:25S-28S

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