Linkage Analysis of Prostate Cancer

Bailey-Wilson, Joan E.

Abstract

This study is a linkage analysis of families with human prostate cancer. A paper published in Science in 1996 by this group indicates the possibility of linkage of a locus for prostate cancer to a region of chromosome 1. A second locus on the X chromosome has been mapped by linkage analysis with results published in Nature Genetics, 20:175-179 (1998). These results have been followed up this year by intensive linkage analyses of additional families to markers in these regions and in other regions that showed some mild evidence of linkage in the initial genome scan. Families have been obtained and genotyped from several regions of the United States, Finland and Sweden. Association analyses have also been performed on data from Finland, Iceland and the U.S. Efforts are also underway to develop additional family resources for this project. These investigators have also joined a national Prostate Cancer Linkage Consortium to try to localize prostate cancer loci more rapidly, and a meta-analysis paper from this consortium describing the evidence for linkage to the chromosome 1 locus in a very large comnbined dataset was submitted for publication in this fiscal year. This project to identify and clone genes for prostate cancer is ongoing. - linkage, prostate cancer, mapping, susceptibility, gene - Human Subjects

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Human Genome Research Institute (NHGRI)
• Type: Intramural Research (Z01)
• Project #: 1Z01HG000107-03
• Application #: 6290318
• Study Section: Special Emphasis Panel (IDRB)
• Support Year: 3
• Fiscal Year: 1999

Institution

• Name: National Human Genome Research Institute
• Country: United States

Publications

Gillanders, Elizabeth M; Xu, Jianfeng; Chang, Bao-li et al. (2004) Combined genome-wide scan for prostate cancer susceptibility genes. J Natl Cancer Inst 96:1240-7

Carpten, J; Nupponen, N; Isaacs, S et al. (2002) Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet 30:181-4

Ho, Gloria Y F; Knapp, Michael; Freije, Diha et al. (2002) Transmission/disequilibrium tests of androgen receptor and glutathione S-transferase pi variants in prostate cancer families. Int J Cancer 98:938-42

Rokman, Annika; Ikonen, Tarja; Seppala, Eija H et al. (2002) Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. Am J Hum Genet 70:1299-304

Baffoe-Bonnie, Agnes B; Kiemeney, Lambertus A L M; Beaty, Terri H et al. (2002) Segregation analysis of 389 Icelandic pedigrees with Breast and prostate cancer. Genet Epidemiol 23:349-63

Xu, Jianfeng; Zheng, S Lilly; Komiya, Akira et al. (2002) Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Nat Genet 32:321-5

Stephan, Dietrich A; Howell, Gareth R; Teslovich, Tanya M et al. (2002) Physical and transcript map of the hereditary prostate cancer region at xq27. Genomics 79:41-50

Verhage, B A; Baffoe-Bonnie, A B; Baglietto, L et al. (2001) Autosomal dominant inheritance of prostate cancer: a confirmatory study. Urology 57:97-101

Powell, I J; Carpten, J; Dunston, G et al. (2001) African-American heredity prostate cancer study: a model for genetic research. J Natl Med Assoc 93:25S-28S

Xu, J; Zheng, S L; Carpten, J D et al. (2001) Evaluation of linkage and association of HPC2/ELAC2 in patients with familial or sporadic prostate cancer. Am J Hum Genet 68:901-11