Following baseline data collection, the twenty-four rhesus monkeys were divided into treatment groups. Twenty of the monkeys have been fed an obesity-inducing diet high in fat and sugar;ten of these monkeys received 40 mg resveratrol twice a day, ten monkeys got a placebo. Four monkeys remained on a healthy weight stable diet without resveratrol to serve as controls. Monkeys were monitored regularly and follow up data collection has occurred at 3, 6, 9, and 12 months. At 12 months, the resveratrol dose was increased to 240 mg twice a day. Data variables include body composition, glucose tolerance test, immune function, eye exams, pulse wave velocity, locomotor activity, learning and memory, and blood chemistry.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000369-03
Application #
8148230
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2010
Total Cost
$247,204
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Swomley, Aaron M; Triplett, Judy C; Keeney, Jeriel T et al. (2017) Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function. J Nutr Biochem 39:169-179
Bernier, Michel; Wahl, Devin; Ali, Ahmed et al. (2016) Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet. Aging (Albany NY) 8:899-916
Hyatt, Jon-Philippe K; Nguyen, Lisa; Hall, Allison E et al. (2016) Muscle-Specific Myosin Heavy Chain Shifts in Response to a Long-Term High Fat/High Sugar Diet and Resveratrol Treatment in Nonhuman Primates. Front Physiol 7:77
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