Twenty-four rhesus monkeys were divided into treatment groups. Twenty of the monkeys were fed an obesity-inducing diet high in fat and sugar; ten of these monkeys received 40 mg resveratrol twice a day for year one, followed by 240mg resveratrol during year 2, ten monkeys got a placebo. Four monkeys remained on a healthy weight stable diet without resveratrol to serve as controls. Monkeys were monitored regularly and follow up data collection occurred every three months. Data variables include body composition, glucose tolerance test, immune function, eye exams, pulse wave velocity, locomotor activity, and blood chemistry. Tissue biopsies were collected at baseline and year 1. The monkeys were sacrificed after 2 years on study and tissue samples were collected, processed and preserved. Analysis of the tissue is ongoing. FIve manuscripts have been published. Tissue analysis is ongoing for the brain, kidneys, liver, and muscle.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000369-09
Application #
9343510
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Swomley, Aaron M; Triplett, Judy C; Keeney, Jeriel T et al. (2017) Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function. J Nutr Biochem 39:169-179
Bernier, Michel; Wahl, Devin; Ali, Ahmed et al. (2016) Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet. Aging (Albany NY) 8:899-916
Hyatt, Jon-Philippe K; Nguyen, Lisa; Hall, Allison E et al. (2016) Muscle-Specific Myosin Heavy Chain Shifts in Response to a Long-Term High Fat/High Sugar Diet and Resveratrol Treatment in Nonhuman Primates. Front Physiol 7:77
Mattison, Julie A; Wang, Mingyi; Bernier, Michel et al. (2014) Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metab 20:183-90
Dhurandhar, Nikhil V; Dhurandhar, Emily J; Ingram, Donald K et al. (2014) Natural infection of human adenovirus 36 in rhesus monkeys is associated with a reduction in fasting glucose 36. J Diabetes 6:614-6
Jimenez-Gomez, Yolanda; Mattison, Julie A; Pearson, Kevin J et al. (2013) Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab 18:533-45
Fiori, Jennifer L; Shin, Yu-Kyong; Kim, Wook et al. (2013) Resveratrol prevents ?-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet. Diabetes 62:3500-13