Noninvasive Evaluation of Pediatric CNS Tumors

Warren, Katherine E.

Abstract

There are several sections of this project involving different aspects of imaging.1. MR sequences: We are currently working in the Laboratory of Diagnostic Radiology Research evaluating multiple MR sequences on children with brain tumors, longitudinally, to assess outcome to tehrapy and prognostic factors. These imaging modalities include spectroscopy (single voxel, CSI and multislice multivoxel), perfusion studies (DEMRI, DSC-MRI) and diffusion tenor imaging.2. Results from NMRS are being compared to the """"""""gold standard"""""""" in adult neuro-oncology, i.e. FDG-PET, to determine the correlation between results of each modality.3. New nuclear medicine studies involving alternate radioisotopes are being evaluated. We have opened a study involving pediatric patients with high grade gliomas or diffuse brainstem tumors who will be evaluated by FLT, FDG and NMRS.The objectives of this study specifically are:Determine the feasibility of 18F-FLT PET imaging in pediatric patients with malignant gliomasDetermine the ability of 18F-FLT PET imaging to detect treatment changes in pediatric patients with malignant gliomas undergoing radiation therapyDetermine the safety and toxicity profile of PET imaging using 18F-FLT in pediatric patients with malignant gliomasTo correlate changes in 18F-FLT PET before and after radiation with outcome (12 month PFS)To compare the performance of 18F-FLT-PET to that of MR perfusion, proton magnetic resonance spectroscopy (1H-MRSI) and 18F-FDG PET in prediction of tumor response, time to progression and overall survival time.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIABC011299-03
• Application #: 8553088
• Support Year: 3
• Fiscal Year: 2012
• Total Cost: $118,698

Institution

• Name: National Cancer Institute Division of Basic Sciences

Publications

Warren, Katherine E; Vezina, Gilbert; Poussaint, Tina Y et al. (2018) Response assessment in medulloblastoma and leptomeningeal seeding tumors: recommendations from the Response Assessment in Pediatric Neuro-Oncology committee. Neuro Oncol 20:13-23

Arvold, Nils D; Armstrong, Terri S; Warren, Katherine E et al. (2018) Corticosteroid use endpoints in neuro-oncology: Response Assessment in Neuro-Oncology Working Group. Neuro Oncol 20:897-906

Warren, Katherine E; Vezina, Gilbert; Poussaint, Tina Y et al. (2018) Response to Harreld re: ""Response assessment in medulloblastoma and leptomeningeal seeding tumors: recommendations from the Response Assessment in Pediatric Neuro-Oncology Committee"". Neuro Oncol 20:144-145

Dang Do, An N; Baker, Eva H; Warren, Katherine E et al. (2018) Spontaneously regressing brain lesions in Smith-Lemli-Opitz syndrome. Am J Med Genet A 176:386-390

Packer, Roger J; Pfister, Stephan; Bouffet, Eric et al. (2017) Pediatric low-grade gliomas: implications of the biologic era. Neuro Oncol 19:750-761

Ranjan, Surabhi; Warren, Katherine E (2017) Gliomatosis Cerebri: Current Understanding and Controversies. Front Oncol 7:165

Warren, Katherine E (2014) Measuring the pons: a non-invasive biomarker for pediatric diffuse intrinsic pontine glioma. CNS Oncol 3:181-3

Steffen-Smith, Emilie A; Baker, Eva H; Venzon, David et al. (2014) Measurements of the pons as a biomarker of progression for pediatric DIPG. J Neurooncol 116:127-33

Chittiboina, Prashant; Heiss, John D; Warren, Katherine E et al. (2014) Magnetic resonance imaging properties of convective delivery in diffuse intrinsic pontine gliomas. J Neurosurg Pediatr 13:276-82

Steffen-Smith, Emilie A; Sarlls, Joelle E; Pierpaoli, Carlo et al. (2014) Diffusion tensor histogram analysis of pediatric diffuse intrinsic pontine glioma. Biomed Res Int 2014:647356