Abstract

There are several sections of this project involving different aspects of imaging. 1. MR sequences: We are currently working in the Laboratory of Diagnostic Radiology Research evaluating multiple MR sequences on children with brain tumors, longitudinally, to assess outcome to tehrapy and prognostic factors. These imaging modalities include spectroscopy (single voxel, CSI and multislice multivoxel), perfusion studies (DEMRI, DSC-MRI) and diffusion tenor imaging. 2. Results from NMRS are being compared to the """"""""gold standard"""""""" in adult neuro-oncology, i.e. FDG-PET, to determine the correlation between results of each modality. 3. New nuclear medicine studies involving alternate radioisotopes are being evaluated. We have opened a study involving pediatric patients with high grade gliomas or diffuse brainstem tumors who will be evaluated by FLT, FDG and NMRS.The objectives of this study specifically are: Determine the feasibility of 18F-FLT PET imaging in pediatric patients with malignant gliomas Determine the ability of 18F-FLT PET imaging to detect treatment changes in pediatric patients with malignant gliomas undergoing radiation therapy Determine the safety and toxicity profile of PET imaging using 18F-FLT in pediatric patients with malignant gliomas To correlate changes in 18F-FLT PET before and after radiation with outcome (12 month PFS) To compare the performance of 18F-FLT-PET to that of MR perfusion, proton magnetic resonance spectroscopy (1H-MRSI) and 18F-FDG PET in prediction of tumor response, time to progression and overall survival time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011299-01
Application #
8157752
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2010
Total Cost
$177,942
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Warren, Katherine E; Vezina, Gilbert; Poussaint, Tina Y et al. (2018) Response assessment in medulloblastoma and leptomeningeal seeding tumors: recommendations from the Response Assessment in Pediatric Neuro-Oncology committee. Neuro Oncol 20:13-23
Arvold, Nils D; Armstrong, Terri S; Warren, Katherine E et al. (2018) Corticosteroid use endpoints in neuro-oncology: Response Assessment in Neuro-Oncology Working Group. Neuro Oncol 20:897-906
Warren, Katherine E; Vezina, Gilbert; Poussaint, Tina Y et al. (2018) Response to Harreld re: ""Response assessment in medulloblastoma and leptomeningeal seeding tumors: recommendations from the Response Assessment in Pediatric Neuro-Oncology Committee"". Neuro Oncol 20:144-145
Dang Do, An N; Baker, Eva H; Warren, Katherine E et al. (2018) Spontaneously regressing brain lesions in Smith-Lemli-Opitz syndrome. Am J Med Genet A 176:386-390
Packer, Roger J; Pfister, Stephan; Bouffet, Eric et al. (2017) Pediatric low-grade gliomas: implications of the biologic era. Neuro Oncol 19:750-761
Ranjan, Surabhi; Warren, Katherine E (2017) Gliomatosis Cerebri: Current Understanding and Controversies. Front Oncol 7:165
Warren, Katherine E (2014) Measuring the pons: a non-invasive biomarker for pediatric diffuse intrinsic pontine glioma. CNS Oncol 3:181-3
Steffen-Smith, Emilie A; Baker, Eva H; Venzon, David et al. (2014) Measurements of the pons as a biomarker of progression for pediatric DIPG. J Neurooncol 116:127-33
Chittiboina, Prashant; Heiss, John D; Warren, Katherine E et al. (2014) Magnetic resonance imaging properties of convective delivery in diffuse intrinsic pontine gliomas. J Neurosurg Pediatr 13:276-82
Steffen-Smith, Emilie A; Sarlls, Joelle E; Pierpaoli, Carlo et al. (2014) Diffusion tensor histogram analysis of pediatric diffuse intrinsic pontine glioma. Biomed Res Int 2014:647356

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