Abstract

There are several sections of this project involving different aspects of imaging. 1. MR sequences: We are currently working in the Laboratory of Diagnostic Radiology Research evaluating multiple MR sequences on children with brain tumors, longitudinally, to assess outcome to therapy and prognostic factors. These imaging modalities include spectroscopy (single voxel, CSI and multislice multivoxel), perfusion studies (DEMRI, DSC-MRI) and diffusion tenor imaging. 2. Results from NMRS are being compared to the gold standard in adult neuro-oncology, i.e. FDG-PET, to determine the correlation between results of each modality. The project, Noninvasive evaluation of Children with Diffuse Intrinsic Pontine Gliomas has been merged with this project to allow for more comprehensive analysis of children with CNS tumors. This project halted due to the PI departure.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011299-10
Application #
10014596
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Warren, Katherine E; Vezina, Gilbert; Poussaint, Tina Y et al. (2018) Response assessment in medulloblastoma and leptomeningeal seeding tumors: recommendations from the Response Assessment in Pediatric Neuro-Oncology committee. Neuro Oncol 20:13-23
Arvold, Nils D; Armstrong, Terri S; Warren, Katherine E et al. (2018) Corticosteroid use endpoints in neuro-oncology: Response Assessment in Neuro-Oncology Working Group. Neuro Oncol 20:897-906
Warren, Katherine E; Vezina, Gilbert; Poussaint, Tina Y et al. (2018) Response to Harreld re: ""Response assessment in medulloblastoma and leptomeningeal seeding tumors: recommendations from the Response Assessment in Pediatric Neuro-Oncology Committee"". Neuro Oncol 20:144-145
Dang Do, An N; Baker, Eva H; Warren, Katherine E et al. (2018) Spontaneously regressing brain lesions in Smith-Lemli-Opitz syndrome. Am J Med Genet A 176:386-390
Packer, Roger J; Pfister, Stephan; Bouffet, Eric et al. (2017) Pediatric low-grade gliomas: implications of the biologic era. Neuro Oncol 19:750-761
Ranjan, Surabhi; Warren, Katherine E (2017) Gliomatosis Cerebri: Current Understanding and Controversies. Front Oncol 7:165
Warren, Katherine E (2014) Measuring the pons: a non-invasive biomarker for pediatric diffuse intrinsic pontine glioma. CNS Oncol 3:181-3
Steffen-Smith, Emilie A; Baker, Eva H; Venzon, David et al. (2014) Measurements of the pons as a biomarker of progression for pediatric DIPG. J Neurooncol 116:127-33
Chittiboina, Prashant; Heiss, John D; Warren, Katherine E et al. (2014) Magnetic resonance imaging properties of convective delivery in diffuse intrinsic pontine gliomas. J Neurosurg Pediatr 13:276-82
Steffen-Smith, Emilie A; Sarlls, Joelle E; Pierpaoli, Carlo et al. (2014) Diffusion tensor histogram analysis of pediatric diffuse intrinsic pontine glioma. Biomed Res Int 2014:647356

Showing the most recent 10 out of 16 publications