Abstract

Participant enrollment was completed for this project in 8/2015, resulting in a sample of 187 military personnel seeking care for a sleep disorder or who served as healthy controls. All participants in this study underwent a polysomonographic sleep evlauation and had blood collected for biomarker measurement which includes proteomics, gene-expression and DNA methyltion. Participants are seen at baseline and then 6 weeks following this. We use follow-up data to examine changes in symptoms with standard of care interventions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIANR000027-03
Application #
9148051
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
National Institute of Nursing Research
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Osier, Nicole; Motamedi, Vida; Edwards, Katie et al. (2018) Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment. Mol Neurobiol :
Motamedi, Vida; Kanefsky, Rebekah; Matsangas, Panagiotis et al. (2018) Elevated tau and interleukin-6 concentrations in adults with obstructive sleep apnea. Sleep Med 43:71-76
Devoto, Christina; Arcurio, Lindsay; Fetta, Joseph et al. (2017) Inflammation Relates to Chronic Behavioral and Neurological Symptoms in Military Personnel with Traumatic Brain Injuries. Cell Transplant 26:1169-1177
Martin, Christiana G; Kim, Hyungsuk; Yun, Sijung et al. (2017) Circulating miRNA associated with posttraumatic stress disorder in a cohort of military combat veterans. Psychiatry Res 251:261-265
Cashion, Ann K; Gill, Jessica; Hawes, Rebecca et al. (2016) National Institutes of Health Symptom Science Model sheds light on patient symptoms. Nurs Outlook 64:499-506
Devoto, Christina; Arcurio, Lindsay; Fetta, Joseph et al. (2016) Inflammation Relates to Chronic Behavioral and Neurological Symptoms in Military with Traumatic Brain Injuries. Cell Transplant :
Livingston, Whitney S; Rusch, Heather L; Nersesian, Paula V et al. (2015) Improved Sleep in Military Personnel is Associated with Changes in the Expression of Inflammatory Genes and Improvement in Depression Symptoms. Front Psychiatry 6:59
Rusch, Heather L; Shvil, Erel; Szanton, Sarah L et al. (2015) Determinants of psychological resistance and recovery among women exposed to assaultive trauma. Brain Behav 5:e00322
Barr, Taura; Livingston, Whitney; Guardado, Pedro et al. (2015) Chapter 8 Military Personnel With Traumatic Brain Injuries and Insomnia Have Reductions in PTSD and Improved Perceived Health Following Sleep Restoration: A Relationship Moderated by Inflammation. Annu Rev Nurs Res 33:249-66
Rusch, Heather L; Guardado, Pedro; Baxter, Tristin et al. (2015) Improved Sleep Quality is Associated with Reductions in Depression and PTSD Arousal Symptoms and Increases in IGF-1 Concentrations. J Clin Sleep Med 11:615-23

Showing the most recent 10 out of 23 publications