Participant enrollment was completed for this project in 8/2015, resulting in a sample of 187 military personnel seeking care for a sleep disorder or who served as healthy controls. All participants in this study underwent a polysomonographic sleep evlauation and had blood collected for biomarker measurement which includes proteomics, gene-expression and DNA methyltion. Participants are seen at baseline and then 6 weeks following this. We use follow-up data to examine changes in symptoms with standard of care interventions. During this year, we have examined exosomes and the role of tau in TBIs from the above study. This year we have begun studies within the Center for Neuroscience and Regenerative Medicine to determine the role of biomarkers in the risk for fatigue and sleep disturbances.

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National Institute of Nursing Research
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Osier, Nicole; Motamedi, Vida; Edwards, Katie et al. (2018) Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment. Mol Neurobiol :
Motamedi, Vida; Kanefsky, Rebekah; Matsangas, Panagiotis et al. (2018) Elevated tau and interleukin-6 concentrations in adults with obstructive sleep apnea. Sleep Med 43:71-76
Devoto, Christina; Arcurio, Lindsay; Fetta, Joseph et al. (2017) Inflammation Relates to Chronic Behavioral and Neurological Symptoms in Military Personnel with Traumatic Brain Injuries. Cell Transplant 26:1169-1177
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Cashion, Ann K; Gill, Jessica; Hawes, Rebecca et al. (2016) National Institutes of Health Symptom Science Model sheds light on patient symptoms. Nurs Outlook 64:499-506
Devoto, Christina; Arcurio, Lindsay; Fetta, Joseph et al. (2016) Inflammation Relates to Chronic Behavioral and Neurological Symptoms in Military with Traumatic Brain Injuries. Cell Transplant :
Livingston, Whitney S; Rusch, Heather L; Nersesian, Paula V et al. (2015) Improved Sleep in Military Personnel is Associated with Changes in the Expression of Inflammatory Genes and Improvement in Depression Symptoms. Front Psychiatry 6:59
Rusch, Heather L; Shvil, Erel; Szanton, Sarah L et al. (2015) Determinants of psychological resistance and recovery among women exposed to assaultive trauma. Brain Behav 5:e00322
Barr, Taura; Livingston, Whitney; Guardado, Pedro et al. (2015) Chapter 8 Military Personnel With Traumatic Brain Injuries and Insomnia Have Reductions in PTSD and Improved Perceived Health Following Sleep Restoration: A Relationship Moderated by Inflammation. Annu Rev Nurs Res 33:249-66
Rusch, Heather L; Guardado, Pedro; Baxter, Tristin et al. (2015) Improved Sleep Quality is Associated with Reductions in Depression and PTSD Arousal Symptoms and Increases in IGF-1 Concentrations. J Clin Sleep Med 11:615-23

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