Participant enrollment was completed for this project in 8/2015, resulting in a sample of 187 military personnel seeking care for a sleep disorder or who served as healthy controls. All participants in this study underwent a polysomonographic sleep evlauation and had blood collected for biomarker measurement which includes proteomics, gene-expression and DNA methyltion. Participants are seen at baseline and then 6 weeks following this. We use follow-up data to examine changes in symptoms with standard of care interventions. During this year, we have examined exosomes and the role of tau in TBIs.

Project Start
Project End
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Budget End
Support Year
4
Fiscal Year
2016
Total Cost
Indirect Cost
Name
National Institute of Nursing Research
Department
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Osier, Nicole; Motamedi, Vida; Edwards, Katie et al. (2018) Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment. Mol Neurobiol :
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