Participant enrollment was completed for the first phase of this project in 9/2012, resulting in a sample of 117 military personnel seeking care for a sleep disorder. We elected to continue recruitment of participants and to develop a second phase to the study. The institutional review board approval of re-initiating this project was approved on 8/13/2013. All participants in this study underwent a polysomonographic sleep evlauation and had blood collected for biomarker measurement which includes proteomics, gene-expression and DNA methyltion. Participants are seen at baseline and then 6 weeks following this. We use follow-up data to examine changes in symptoms with standard of care interventions. Accomplishments include data-based publications as well as presentations by this group. These include the following: Publications: Gill, J.M., Lee, H., Saligan, L., Szanton, Women in recovery from PTSD have similar inflammation and quality of life as non-traumatized controls, Journal of Psychosomatic Research, Online Release December 2012 Mysliwiec V, Gill J, Lee H, Baxter T, Pierce R, Barr TL, Krakow B, Roth BJ, Sleep Disorders in U.S. Military Personnel: A High Rate of Comorbid Insomnia and Obstructive Sleep Apnea. CHEST, Online Release May 16, 2013. Gill, J. Lee H, Baxter T, Pierce R, Barr TL, Krakow B, Mysliwiec V. Adherence with CPAP in OSA Patients is Linked to Increases in IGF-1 and Reductions in Symptoms of PTSD. (Accepted Psychosomatic Medicine)

Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2013
Total Cost
$742,562
Indirect Cost
Name
National Institute of Nursing Research
Department
Type
DUNS #
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Gill, Jessica M; Lee, Hyunhwa; Baxter, Tristin et al. (2015) A Diagnosis of Insomnia Is Associated With Differential Expression of Sleep-Regulating Genes in Military Personnel. Biol Res Nurs 17:384-92
Rusch, Heather L; Shvil, Erel; Szanton, Sarah L et al. (2015) Determinants of psychological resistance and recovery among women exposed to assaultive trauma. Brain Behav 5:e00322
Mysliwiec, Vincent; Gill, Jessica; Matsangas, Panagiotis et al. (2015) IGF-1: a potential biomarker for efficacy of sleep improvement with automatic airway pressure therapy for obstructive sleep apnea? Sleep Breath :
Rusch, Heather L; Guardado, Pedro; Baxter, Tristin et al. (2015) Improved Sleep Quality is Associated with Reductions in Depression and PTSD Arousal Symptoms and Increases in IGF-1 Concentrations. J Clin Sleep Med 11:615-23
Mysliwiec, Vincent; Matsangas, Panagiotis; Gill, Jessica et al. (2015) A Comparative Analysis of Sleep Disordered Breathing in Active Duty Service Members with and without Combat-Related Posttraumatic Stress Disorder. J Clin Sleep Med :
Mysliwiec, Vincent; Capaldi 2nd, Vincent F; Gill, Jessica et al. (2015) Adherence to positive airway pressure therapy in U.S. military personnel with sleep apnea improves sleepiness, sleep quality, and depressive symptoms. Mil Med 180:475-82
Livingston, Whitney S; Rusch, Heather L; Nersesian, Paula V et al. (2015) Improved Sleep in Military Personnel is Associated with Changes in the Expression of Inflammatory Genes and Improvement in Depression Symptoms. Front Psychiatry 6:59
Olivera, Anlys; Lejbman, Natasha; Jeromin, Andreas et al. (2015) Peripheral Total Tau in Military Personnel Who Sustain Traumatic Brain Injuries During Deployment. JAMA Neurol :
Roy, Michael J; Costanzo, Michelle; Gill, Jessica et al. (2015) Predictors of Neurocognitive Syndromes in Combat Veterans. Cureus 7:e293
Barr, Taura; Livingston, Whitney; Guardado, Pedro et al. (2015) Chapter 8 Military Personnel With Traumatic Brain Injuries and Insomnia Have Reductions in PTSD and Improved Perceived Health Following Sleep Restoration: A Relationship Moderated by Inflammation. Annu Rev Nurs Res 33:249-66

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