The objectives of this record-linkage investigation are (10 to assemble a roster of patients who were diagnosed with ataxia-telangiectasia (AT); (2) to evaluate the occurance of cancer in these individuals; (3) to identify first degree relatives (parents, offspring, and siblings), and second degree relatives to the extent feasible (grandparents, aunts, uncles, and cousins) and link rosters of these relatives to cancer registry records to determine the occurrence of cancers; and (4) to obtain blood and tissue samples on patients and their relatives for molecular evaluation. A molecular evaluation will provide important knowledge on the role of genetic predisposition in the carcinogenic process.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP061038-001
Application #
2595069
Study Section
Project Start
1996-09-30
Project End
1998-09-29
Budget Start
1997-06-19
Budget End
1998-09-29
Support Year
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Danish Cancer Society
Department
Type
DUNS #
City
Copenhagen
State
Country
Denmark
Zip Code
Vihinen, M; Arredondo-Vega, F X; Casanova, J L et al. (2001) Primary immunodeficiency mutation databases. Adv Genet 43:103-88
Laake, K; Jansen, L; Hahnemann, J M et al. (2000) Characterization of ATM mutations in 41 Nordic families with ataxia telangiectasia. Hum Mutat 16:232-46