Abstract

This is the renewal of a project that is developing an integrated genetic resource for investigations of complex traits in the vervet monkey (Cercopithecus aethiops), also known as the African Green monkey. Genetic investigation of complex traits will increasingly include a combination of traditional genetic mapping with identification of candidate genes through gene expression profiling. The renewal of this project will produce an integrated genomewide genetic reference map consisting of microsatellite and single nucleotide polymorphism (SNP) markers. The development of a microarray resource, covering a wide range of brain and non-brain tissues, at several points of development will enable investigations of gene expression in the vervet. Magnetic resonance imaging (MRI) studies will provide anatomic guidance for dissection of brain tissues for microarrays. The tools generated from this project will facilitate investigation of a wide range of human diseases and traits, including complex behaviors and infectious diseases. The utility of such studies derives from the fact that humans are much more similar to other primates than they are to other model organisms such as the mouse. The worldwide shortage of rhesus macaques for biomedical research has created a tremendous need for alternative non-human primate models. Vervets share many biological and behavioral similarities with macaques and are readily available to researchers. This project will further enhance the value of the vervet for biomedical research. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
5R01RR016300-04
Application #
6935339
Study Section
Genome Study Section (GNM)
Program Officer
Harding, John D
Project Start
2002-09-01
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
4
Fiscal Year
2005
Total Cost
$830,085
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Garcia, Erin I; Emerman, Michael (2018) Recurrent Loss of APOBEC3H Activity during Primate Evolution. J Virol :
Turner, Trudy R; Schmitt, Christopher A; Cramer, Jennifer Danzy et al. (2018) Morphological variation in the genus Chlorocebus: Ecogeographic and anthropogenically mediated variation in body mass, postcranial morphology, and growth. Am J Phys Anthropol 166:682-707
Schmitt, C A; Service, S K; Jasinska, A J et al. (2018) Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus). Int J Obes (Lond) 42:765-774
Jasinska, Anna J; Zelaya, Ivette; Service, Susan K et al. (2017) Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate. Nat Genet 49:1714-1721
Svardal, Hannes; Jasinska, Anna J; Apetrei, Cristian et al. (2017) Ancient hybridization and strong adaptation to viruses across African vervet monkey populations. Nat Genet 49:1705-1713
Turner, Trudy R; Coetzer, Willem G; Schmitt, Christopher A et al. (2016) Localized population divergence of vervet monkeys (Chlorocebus spp.) in South Africa: Evidence from mtDNA. Am J Phys Anthropol 159:17-30
Senghore, Madikay; Bayliss, Sion C; Kwambana-Adams, Brenda A et al. (2016) Transmission of Staphylococcus aureus from Humans to Green Monkeys in The Gambia as Revealed by Whole-Genome Sequencing. Appl Environ Microbiol 82:5910-7
Kuokkanen, Satu; Polotsky, Alex J; Chosich, Justin et al. (2016) Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med 62:227-42
Bailey, Adam L; Lauck, Michael; Sibley, Samuel D et al. (2016) Zoonotic Potential of Simian Arteriviruses. J Virol 90:630-5
Turner, Trudy R; Cramer, Jennifer Danzy; Nisbett, Alexis et al. (2016) A comparison of adult body size between captive and wild vervet monkeys (Chlorocebus aethiops sabaeus) on the island of St. Kitts. Primates 57:211-20

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