This project will develop an integrated genetic and genomic resource for investigations of the central nervous system (CNS), metabolism, and immunity. Progress in the past included the completion of a genetic map consisting of microsatellite markers, the identification of large numbers of single nucleotide polymorphisms (SNPs) in targeted genome regions and the generation of an initial resource for gene expression studies. A genome sequencing project is now underway and will provide, in addition to a reference sequence, a reference transcriptome, and genome wide information on common variation. The renewal will use this information to verify genomic rearrangements, and generate a genome wide SNP array. By assembling and then genotyping using this array we will carry out proof-of- concept genome wide association studies of several heritable traits. We will also extend the transcriptome resource through evaluation of inter-individual variation in expression. All of the information generated through this project will be made available to the scientific community through an integrated regularly updated website.

Public Health Relevance

This project will develop research tools which will facilitate a wide range of different investigations that could advance our understanding of a number of devastating common diseases. Notable examples include HIV/AIDS, mental disorders, and diabetes. These tools will allow researchers to uncover specific alterations in the genome - the sum of genetic material - that predispose towards or protect against such diseases.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
5R01RR016300-08
Application #
7895500
Study Section
Genomics, Computational Biology and Technology Study Section (GCAT)
Program Officer
Harding, John D
Project Start
2001-07-01
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
8
Fiscal Year
2010
Total Cost
$661,626
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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