This is the renewal of a project that is developing an integrated genetic resource for investigations of complex traits in the vervet monkey (Cercopithecus aethiops), also known as the African Green monkey. Genetic investigation of complex traits will increasingly include a combination of traditional genetic mapping with identification of candidate genes through gene expression profiling. The renewal of this project will produce an integrated genomewide genetic reference map consisting of microsatellite and single nucleotide polymorphism (SNP) markers. The development of a microarray resource, covering a wide range of brain and non-brain tissues, at several points of development will enable investigations of gene expression in the vervet. Magnetic resonance imaging (MRI) studies will provide anatomic guidance for dissection of brain tissues for microarrays. The tools generated from this project will facilitate investigation of a wide range of human diseases and traits, including complex behaviors and infectious diseases. The utility of such studies derives from the fact that humans are much more similar to other primates than they are to other model organisms such as the mouse. The worldwide shortage of rhesus macaques for biomedical research has created a tremendous need for alternative non-human primate models. Vervets share many biological and behavioral similarities with macaques and are readily available to researchers. This project will further enhance the value of the vervet for biomedical research. ? ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
5R01RR016300-06
Application #
7257180
Study Section
Genome Study Section (GNM)
Program Officer
Harding, John D
Project Start
2002-09-01
Project End
2009-07-16
Budget Start
2007-07-01
Budget End
2009-07-16
Support Year
6
Fiscal Year
2007
Total Cost
$288,271
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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Turner, Trudy R; Cramer, Jennifer Danzy; Nisbett, Alexis et al. (2016) A comparison of adult body size between captive and wild vervet monkeys (Chlorocebus aethiops sabaeus) on the island of St. Kitts. Primates 57:211-20
Turner, Trudy R; Coetzer, Willem G; Schmitt, Christopher A et al. (2016) Localized population divergence of vervet monkeys (Chlorocebus spp.) in South Africa: Evidence from mtDNA. Am J Phys Anthropol 159:17-30

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